摘要
目的:了解氟喹诺酮类抗菌药物在临床治疗中发生不良反应的情况,探讨其不良反应的特点和规律。方法:采用回顾性分析方法,收集2005年1月—2008年12月中国医院数字图书馆期刊全文库中氟喹诺酮类抗菌药物所致不良反应病例和广东药学院附属第一医院同期氟喹诺酮类抗菌药物所致不良反应的报表进行统计分析。结果:氟喹诺酮类抗菌药物引起不良反应涉及到不同年龄,男性多于女性,静脉注射最容易引起ADR。发生ADR的氟喹诺酮类抗菌药物以左氧氟沙星最多,其中皮肤及其附件损害最多。结论:导致氟喹诺酮类抗菌药物发生不良反应的因素很多,临床应用时应该注意不良反应的监测,合理用药,以提高用药的安全性,减少ADR发生。
OBJECTIVE：To probe into the occurrence,characteristics and regularities of the adverse drug reactions（ADR）induced by fluoroquinolones.METHODS：A retrospective statistical analysis was carried out on fluoroquinolones-induced ADR cases indexed in the Chinese Journal Full-text Digital Library Hospital Library（Jan.2005-Dec.2008）and the concurrent fluoroquinolones-induced ADR cases reported in our hospital.RESULTS：Fluoroquinolones-induced ADR occurred in different age with males showing higher percentage than females,and which were most likely caused via intravenous injection.Of all the fluoroquinolones-induced ADR,levofloxacin-induced ADR was more frequent.The ADR manifested itself more often as lesions of skin and its appendants.CONCLUSION：Fluoroquinolones-induced ADR is associated with many factors,therefore,ADR monitoring should be tightened and rational use of fluoroquinolones should be emphasized to enhance the safety of medication and reduce the incidence of ADR.
出处
《中国医院用药评价与分析》
2011年第5期465-468,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
