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活血渗湿方抗肝纤维化作用的实验研究 被引量:11

Experimental Study about Huoxue Shenshi Decoction's Anti-fibrosis in Liver
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摘要 用四氯化碳致大鼠肝纤维化模型进行活血渗湿方药效试验,以秋水仙碱作对照。治疗6周以后,治疗组谷雨转氨酶(ALT)活性及透明质酸(HA)指标均明显下降,白蛋白(ALb),白、球蛋白比例(A/G)明显增高,与秋水仙碱对照组比较有显著性差异;肝细胞变性、坏死比对照组明显减轻,肝纤维化程度也明显轻于对照组。表明活血渗湿方能明显改善肝功能,其降低血清肝纤维化指标HA的作用明显优于秋水仙碱。 Make a model with carbon tetrachloride and make a pharmacodynamic test with huoxue shenshi decoction, colchicine being the control. 6 weeks later choose serum glutamic pyruvic transaminase (SGPT) activity, albumin (AIb), the rate of Alb and globulin (A/G), hyaluronic acid (HA) and the changes in histology as determination indexes. The experimental result: ①Im the therapeutic group the indexes of ALT activity and A/G are obviously higher, there is a definite difference compared with colchicine. ②Histological changes: In the therapeutic group, the degeneration and necrosis are obviously less than that in the control group and also the degree of fibrosis in liver. So it shows that huoxue shenshi decoction can definitely improve liver function, its HA index of anti-fibrosis in liver is greatly better than colchicine.
机构地区 浙江中医学院
出处 《浙江中医学院学报》 1999年第4期47-48,共2页 Journal of Zhejiang College of Traditional Chinese Medicine
关键词 活血渗湿方 肝纤维化 实验 中医药疗法 huoxue shenshi decoction liver fibrosis experimental study
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