14种抗菌药物对铜绿假单胞菌的抗生素后效应

The postantibiotic effects of Ps.aeruginosa 

目的：研究１４ 种抗菌药物对医院内感染常见致病菌－ 铜绿假单胞菌的抗生素后效应（ＰＡＥ） 。方法：采用ＡＶＡＮＴＡＧＥ微生物分析仪的吸光度法测定ＰＡＥ。结果：碳青霉烯类对铜绿假单胞菌的抗菌作用较强，ＰＡＥ较长；氟喹诺酮类抗菌药物的ＰＡＥ很长，可达２ ～４ ｈ，呈显著的浓度依赖性；氨基糖苷类对铜绿假单胞菌有一定的ＰＡＥ，而青霉素类、头孢菌素类和磷霉素对铜绿假单胞菌ＰＡＥ则较短。结论：碳青霉烯类、氟喹诺酮类和氨基糖苷类对铜绿假单胞菌的ＰＡＥ较长，临床在设计给药方案时应重视ＰＡＥ因素。

OBJECTIVE:The postantibiotic effects(PAE) of fourteen antimicrobial agents against nosocomial infections pathogens Ps.aeruginosa were studied.METHODS:PAEs were determined by use of spectrophotometric method.RESULTS:The antibacterial actibity of carbenpenems against Ps.aeruginosa was strong and PAEs were longer;the PAEs of fluroquinolones against Ps.aeruginosa were long and up to 2～4 h and showed marked concentration dependent;the PAEs of aminoglycosides were obvious,but PAEs of penicillins,cephalosporins and fosfomycin against Ps aeruginosa were short.CONCLUSIONS:There were longer PAEs of carbenpenems,fluroquinolones and aminoglycosides.It suggested that PAE should be paid attention while designing the dosing schedule.