腺性膀胱炎电灼术后药物膀胱灌注治疗效果的比较

Comparison of mitomycin and pirarubicin bladder perfusion after transurethral resection in treating cystitis glandularis

目的对比观察经尿道电切术后分别应用丝裂霉素和吡柔比星药物灌注治疗腺性膀胱炎的疗效。方法选择2006年6月～2009年10月72例腺性膀胱炎患者,均行经尿道电切治疗,术后根据不同药物灌注治疗分为两组。34例行丝裂霉素药物灌注,38例吡柔比星药物灌注。随访1～2年,观察临床效果。结果丝裂霉素组有15治愈;12例好转,6例无效;吡柔比星组有18治愈,14例好转,7例无效。两组有效率差异有显著性(P>0.05)。两组患者不良反应发生率比较差异无显著性(P>0.05)。结论经尿道电切术后丝裂霉素和吡柔比星药物灌注两种方法治疗治疗腺性膀胱炎效果相当,不良反应可耐受。

[Objective] To compare the effect of bladder perfusion of mitomycin and pirarubicin after transurethral resection in treating cystitis glandularis. [Methods] 72 cases of cystitis glandularis were divided into two groups according to drug for instillation. All patients were received transurethral resection. One week after operation, 34 cases were treated with mitomycin perfusion and 38 were treated with pirarubicin perfusion. The effects of two groups were observed and compared after one to two years follow up. [Results] The total effective rates in the mitomycin group and pirarubicin group were 79.41% and 84.21% respectively, there was no significant difference between them （P 0.05）. There was no significant difference of adverse reaction between the two groups （P 0.05）. [Conclusion] Mitomycin and pirarubicin bladder perfusion have the similar clinical effect with tolerable side effect .