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真武汤对慢性心力衰竭大鼠心肌细胞凋亡的影响 被引量:22

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摘要 目的观察真武汤对慢性心力衰竭(CHF)大鼠心肌细胞凋亡的影响。方法大鼠随机分为假手术组,模型组,真武汤组,依那普利组。采用腹主动脉缩窄法制作CHF大鼠模型,术后4周开始灌胃给药,连续给药6周。检测血流动力学指标,RT-PCR和Western Blot法检测大鼠心肌组织Bcl-2、Bax mRNA和蛋白的表达。结果与模型组相比,真武汤组LVEDP、+dp/dtmax明显下降,MBP、-dp/dtmax、HR明显上升,Bax表达下降,Bcl-2表达上升。结论真武汤可通过降低Bax在心肌细胞中的表达,调节Bcl-2和Bax平衡来改善CHF大鼠的心功能。
出处 《中国中医急症》 2011年第6期909-910,共2页 Journal of Emergency in Traditional Chinese Medicine
基金 安徽省教育厅自然科学研究项目(编号:KJ2009A043Z)
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参考文献6

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