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米非司酮抗早孕蜕膜雌、孕激素受体的免疫组织化学研究 被引量:58

The Immunohistochemical Studies on Estradiol and Progesterone Receptors in Human Decidua after Terminating Early Pregnancy by Mifepristone
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摘要 目的了解米非司酮及米索前列醇(米索)对人早孕蜕膜雌激素受体(ER)、孕激素受体(PR)的影响。方法取正常早孕、服米非司酮及服米非司酮配伍米索后各10例的蜕膜,应用单克隆抗体链菌素亲生物蛋白过氧化酶(SP)免疫组织化学方法及电子计算机图象分析技术,观察ER、PR的变化。结果正常早孕蜕膜ER和PR位于大部分蜕膜间质细胞及少数腺上皮细胞胞核内,受体水平积分ER为5860790±311691,PR为4905970±157319;服米非司酮后蜕膜ER、PR水平积分为3547180±191858、3700750±188322;服米非司酮配伍米索后蜕膜ER和PR水平积分为2021721±145281、2528580±240535。3者间差异有显著性(P<0.05,P<0.01)。结论米非司酮及米索可使早孕蜕膜ER、PR水平下降,这可能与药物流产后子宫出血时间长有关。 Objective To investigate the effects of mifepristone on decidua at the cellular level of estrogen receptor (ER) and progesterone receptor(PR) and the mechanism of prolonged uterine bleeding after terminating early pregnancy by mifepristone. Methods Thirty decidua specimens were obtained from pregnant women with amenorrhea of 67 week duration, 20 women were treated with mifepristone and 10 given mifepristone plus misoprostol respectively. Immunocytochemical reactions of PR nad ER in decidua were compared among three groups using computer image analysis technology. Results In the control group,the nuclei of the decidual cells were stained positively for ER and PR. Their integral values of receptor level were 5 860 790311 691 for ER and 4 905 970157 319 for PR.Mifepristone treatment reduced ER and PR staining.The integral values were 3 547 180191 858 for ER and 3 700 750188 322 for PR in this group, and it was more apparent in the group treated with mifepristone plus misoprostol:2 021 721145 281 for ER and 2 528 580240 535 for PR. Conclusions The ER and PR level in human decidua decreased after mifepristone or/and misoprostol treatment. This may be related to prolonged uterine bleeding after terminating early pregnancy by mifepristone
出处 《中华妇产科杂志》 CAS CSCD 北大核心 1999年第5期275-277,I007,共4页 Chinese Journal of Obstetrics and Gynecology
关键词 米非司酮 雌激素 受体 孕激素 蜕膜 药物流产 MifepristoneReceptors,estrogenReceptors, progesteroneImmunohistochemistryDecidua
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