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组织型基质金属蛋白酶抑制剂对肿瘤的正调控作用 被引量:1

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摘要 组织型基质金属蛋白酶抑制剂(tissue inhibitors of matrix metalloproteinase,TIMPs)家族是体内存在的一种天然的基质金属蛋白酶(matrix metalloproteinases,MMPs)抑制剂,主要作用为调节基质金属蛋白酶的功能,并具有调节细胞增殖、血管新生等作用,参与了细胞外基质(extracellular matrix,ECM)更新、重构、机体发育,细胞生长、分化,肿瘤的浸润与转移等多种生理及病理过程。在肿瘤浸润及转移方面,理论上TIMPs能通过抑制MMPs活性而阻断肿瘤浸润及转移,
出处 《南昌大学学报(医学版)》 CAS 2011年第3期99-101,104,共4页 Journal of Nanchang University:Medical Sciences
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