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丁胺卡那霉素地塞米松复方脂质体在兔眼玻璃体内的药代动力学研究 被引量:1

Intravitreal phannacokinetics of liposome-encapsulated amikacin and dexamethasone in a rabbit model
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摘要 目的 应用丁胺卡那霉素地塞米松(丁卡地塞)复方脂质体玻璃体内注射以延长两种药物的半衰期.方法 大白兔随机分4组,正常眼2组和眼内炎眼2组均分别注射复方脂质体和游离药物.结果 丁卡在正常眼复方脂质体的半衰期较游离药物延长1.8倍,在眼内炎眼延长3.4倍.地塞在正常眼复方脂质体半衰期较游离药物延长22.5倍,在眼内炎眼延长46.2倍.结论 丁卡地塞复方脂质体玻璃体内注射使丁卡和地塞两种药物的半衰期有明显延长. This study uses liposome - encapsulated amikacin and dexamethasone in vitreous to prolong half - life of the two drugs. Methods White rabbits were randomly distributed into 4 groups. The two normal groups and the two endophthalmitis groups all received respectively intravitreal injection of liposome or dexamethasone and amikacin in PBS. Results The half - life of amikacin in vitreous, the liposome preparation gave a 1.8 - fold increase in normal eyes and a 3.4 - fold increase in eyes with endophthalmitis compared with amikacin in PBS. The half - life of dexamethasone in vitreous, the liposome preparation gave a 22.5 - fold increase in normal eyes and a 46.2 - fold increase in eyes with endophthalmitis compared with dexamethasone in PBS. Conclusion The liposome - encapsulated amikacin and dexamethasone in vitreous prolonged half - life of the two drugs obviously.
出处 《眼外伤职业眼病杂志》 北大核心 1999年第6期529-530,共2页 Journal of Injuries and Occupational Diseases of the Eye with Ophthalmic Surgeries
基金 卫生部基金资助 基金号:94-1-139
关键词 脂质体 丁胺卡那霉素 地塞米松 玻璃体 半衰期 Liposome Amikacin Dexamethasone Pharma-cokinetics
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