评多项肿瘤标记物对卵巢癌的诊断价值

A STRUDY ON THE DIAGNOSTIC VALUE OF MULTIPLE TUMOR MARKS FOR OVARIAN CANCER

目的：为了提高卵巢恶性肿瘤早期诊断的敏感性、特异性及病情监测的效率，筛选出较敏感的肿瘤标记物及联合检测方案。方法：检测了５０ 例卵巢恶性肿瘤、３０ 例卵巢良性肿瘤及２５ 例正常妇女血清中ＣＡ１５３ 、ＣＡ１２５ 、ＬＳＡ、ＴＳＧＦ含量。结果：单项检测的诊断效率从大至小依次为ＣＡ１２５ 、ＬＳＡ、ＴＳＧＦ、ＣＡ１５３ ，联合方案中以ＣＡ１２５ ＋ ＴＳＧＦ诊断效率最大。临床Ⅰ～Ⅱ期患者ＣＡ１２５ ＋ ＴＳＧＦ的敏感性及特异性较ＣＡ１２５ 单项检测明显提高。结论：ＣＡ１２５和ＴＳＧＦ二项的联合检测对卵巢恶性肿瘤的早期诊断及病情的有效监测有一定价值。

To evaluate the diagnostic value of multiple tumor marks,to improve the test sensitivity and specificity,and to select sensitive marks and combined examination program for ovarian cancer.Methods:50 cases of malignant ovary tumors,30 cases of benign ovary tumors and 25 cases of normal ovary tissues were investigated for the contents of serous CA 153 、CA 125 、LSA and TSGF.Results:CA 125 had the most efficient diagnostic value among all single tumor marks,then come LSA、TSGF and CA 153 in turn.CA 125 +TSGF was the best program among all combined diagnostic programs.The diagnostic sensitivity and specificity of CA 125 +TSGF was obviously superior to that of CA 125 alone in climical stage Ⅰ-Ⅱ patients.Conclusions:The combined test program of CA 125 +TSGF is valuble for early diagnosing and monitoring malignant ovary tumors.