血清a-L-岩藻糖苷酶和甲胎蛋白在原发性肝癌中的临床应用

The diagnostic value of the combined detection of serum AFP with AFU in primary hepatic carcinoma

目的探讨血清甲胎蛋白(AFP)和a-L-岩藻糖苷酶(AFU)联合检测对原发性肝癌诊断的临床价值。方法对60例原发性肝癌组、32例其他肿瘤组和42例健康体检组血清AFP和AFU同步测定并进行对照。结果原发性肝癌患者血清AFP、AFU水平及阳性率均明显高于健康对照组及其他肿瘤组,差异有统计学意义(P<0.05);联合检测的敏感性和准确性均高于单项检测。结论联合检测血清中的AFP和AFU能提高原发性肝癌诊断的敏感性和准确性。

Objective To investigate the value of the detection of serum AFP combined with AFU in the diagnosis of primary hepatic carcinoma（PHC）.Methods AFP and AFU were measured simultaneously in 60 patients with PHC,22 patients with other carcinoma and 42 normal subjects.The diagnostic value of all groups were evaluated.Results The serum levels of AFP and AFU in PHC group were significantly higher than those of other groups（P0.05）,Meanwhile,the rates of positivity and accuracy for the combined detection of the two biomarkers were obviously higher than those for any single biomarker（P0.05）.Conclusion The determination of AFP association with AFU would improve the diagnosis in patients with PHC.