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胸腺上皮肿瘤生物学行为的分子标志研究进展 被引量:1

Advance in research of molecular markers of thymic epithelial tumors
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摘要 目的:研究相关分子标志在胸腺上皮肿瘤(TETs)中的表达水平,以及与胸腺上皮肿瘤增殖,侵袭和转移等恶性生物学行为的关系。方法:应用计算机检索PubMed及CNKI期刊全文数据库检索系统,以"胸腺上皮肿瘤、分子标志、生物学行为"等为关键字,检索2004-10-31-2010-10-31的相关文献。共检索到英文文献59篇,中文文献88篇。通过查找全文,排除重复研究和与本研究无关的文献,最后精选纳入分析的文献23篇。结果:多种分子标志与胸腺上皮肿瘤的增殖、侵袭、转移等恶性生物学行为密切相关,是影响恶性肿瘤预后的指标。检测这些分子标志提高了TETs检测的敏感性和特异性,能有效对TETS进行早期筛查、诊断、连续检测和治疗效果的评估、转移复发的预测,有非常大的临床应用价值。结论:通过检测TETs相关标志将有助于TETs的早期诊断和疗效、预后评估。 OBJECTIVE: To explore the level of associated molecular markers in thymic epithelial tumors and its correlation with malignent biological behavior of thymic epithelial tumors.METHODS: The papers published from 10-31-2004 to 10-31-2010 were searched from PubMed and CNKI with the key words "thymic epithelial tumor,molecular markers,biological behavior" respectively or combinedly.A total of 59 relevant articles in English,88 in Chinese were retrieved.The articles that were repetitive studies and had no relations with the study in tumor were excluded,and 23 articles were included in references finally.RESULTS: Malignant biological behaviors such as the proliferation,invasion and migration of thymic epithelial tumor are closely correlated with several genes,which can act as indicators for the prognosis of malignant tumors.Detection of the tumor markers has provided powerful tool in detecting TETs with high sensitivity and specificity.CONCLUSION: The detection of associated molecular markers in thymic epithelial tumors is of great utility for the diagnosis and prognosis of TETs.
作者 张华 王洲
出处 《中华肿瘤防治杂志》 CAS 2011年第13期1057-1060,共4页 Chinese Journal of Cancer Prevention and Treatment
关键词 胸腺上皮肿瘤 分子标志 生物学行为 基因 综述文献 thymic epithelial tumors molecular markers biological behavior genes review literature
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