乙肝病毒父婴垂直传播感染率的临床调查

Clinical investigation on the vertical transmission of hepatitis B virus from father to neonate

目的调查研究乙型肝炎病毒（hepatitis Bvirus，HBV）父婴垂直传播感染率的情况。方法以56对感染HBV的父亲而母亲无HBV标志物的夫妇新生儿脐血做研究组，以10对均不携带HBV的夫妇新生儿脐血做为对照组，分别做HBVPCR检测。结果在研究组的脐血标本中检出2例HBVDNA阳性标本，而这2例新生儿的父亲均是HBsAg（＋）HBeAg（＋）HBcAb（＋）型HBV感染者，对照组脐血均未检出HBVDNA阳性标本。结论HBV可能通过感染HBV的男性传递给下一代。

Objective To investigate the infection and prevalence of hepatitis B virus （HBV） in the neonates whose fathers were positive with hepatitis B virus surface antigen （HBsAg）. Methods HBV DNA were detected in 56 neonates whose fathers were HBsAg positive and mothers were without HBV markers, 10 neonates whose parents were both negative for any HBV markers were as controls. Results There were 2 positive HBV DNA samples in study group, and the HBV markers of the 2 neonates＇fathers were HBsAg（ ＋ ） HBeAg（ ＋ ） HBcAb（ ＋ ） ,while the detection of HBV DNAs were all negative in the control group. Conclusion HBV may transmit to next generation through the male with HBsAg（ ＋ ）.