摘要
1997年对内皮祖细胞的发现和认识,迅速改变了人们对血管生成的认知。在其后的10多年时间里,随着对内皮祖细胞的诱导、培养、鉴定、分化、迁移及归巢等研究的广泛开展,将其用于临床心血管疾病治疗的研究也有了巨大的突破;内皮祖细胞可以促进心肌梗死后梗死区域内的毛细血管新生,改善心脏功能,同时也是构建心血管组织工程的新生力量。现总结近年来内皮祖细胞的鉴定、功能及心血管病治疗方面的研究进展,并对其在再生医学领域的应用做出展望。
The first description of endothelial progenitor cells in 1997 rapidly lead to substantial changes in our understanding of angiogenesis.In the subsequent 10 years researchers have investigated methods of inducing,isolating and culturing endothelial progenitor cells,as well as identification and differentiation,resulting in endothelial progenitor cells emerging as a promising candidate for treating ischemic heart disease.Studies have shown that the introduction of endothelial progenitor cells can restore tissue vascularization,as well as target tumor growth.This review examines the general features and functions of endothelial progenitor cells currently being investigated,and includes some perspectives on the future of endothelial progenitor cell therapy.
出处
《心血管病学进展》
CAS
2011年第4期528-531,共4页
Advances in Cardiovascular Diseases
关键词
内皮祖细胞
血管再生
组织工程
endothelial progenitor cells
vascularization
tissue engineering
