三叉神经痛患者血液降钙素基因相关肽的观察

Observation of calcitonin gene-related peptide in blood of the patients with trigeminal neuralgia.

目的 :观察三叉神经痛发作时是否有降钙素基因相关肽参与 ,加深对三叉神经痛发病机理的认识。方法 :用放射免疫法检测 7例三叉神经痛患者疼痛发作时患侧颈外静脉血、肘静脉血及术后患侧颈外静脉血中降钙素基因相关肽的含量。结果 :发现疼痛发作时患侧颈外静脉血中降钙素基因相关肽含量显著高于肘静脉血及术后患侧颈外静脉血中降钙素基因相关肽的含量。结论 :我们认为 :三叉神经痛的痛支神经过度合成和释放降钙素基因相关肽可能促进了P物质的释放 ,导致阵发性剧烈疼痛 ,并在局部形成神经源性炎症。

Objective: To observe whether calcitonin gene-related peptide participates in the attack of trigeminal neuralgia and get a deeper understanding about its pathogenetic mechanism. Methods: Seven patients were studied, during the attacks venous blood was sampled from both the external jugular vein and cubital fossa vein ipsilateral to the pain, after operations the venous blood from external jugular vein was sampled again. Plasma levels of calcitonin gene-related peptide were determined using sensitive radioimmunoassays. Results: During the attacks of trigeminal neuralgia the levels of calcitonin gene-related peptide in external jugular vein blood were significantly higher than that in cubital fossa vein blood and postoperative external jugular vein blood. Conclusion: Exccesive synthetise and release of calcitonin gene-related peptide in trigeminal nerve may promote release of substance P, cause the intense paroxysmal pain and form a local neurogenic inflammation.