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激素性股骨头缺血坏死动物模型诱导过程中凝血指标的初步检测及其意义 被引量:2

Preliminary Detection and Its Significance of Coagulative Index in Steroid induced Necrosis of the Femoral Head
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摘要 目的 :初步分析前凝血状况下诱导激素性股骨头缺血坏死过程中 ,系统的凝血状况及相互关系。方法 :选中国大白兔 2 1只分为 3组。A组 :7只 ,先静脉注射大肠杆菌内毒素 2次 ,每次 10 0 μg/kg ,间隔 2 4h。在第 2次注射完后即肌肉注射甲基强的松龙 3次 ,每次 2 0mg/kg ,间隔 2 4h。B组 :10只 ,肌肉注射甲基强的松龙 3次 ,每次 2 0mg/kg ,间隔2 4h。C组 :4只 ,对照组。结果 :A组在第 2次注射完内毒素与B组在第 3次注射完激素后 1、2、3d血小板比较差异显著(P <0 0 1)。A组在第 2次注射完内毒素与B组在第 3次注射完激素后 3d凝血时间比较差异显著 (P <0 0 1)。结论 :系统凝血是激素导致股骨头缺血坏死发病过程中的重要环节。 Objective:Preliminarily analyses the relationship between systemic coagulation and steroid induced necrosis of the femoral head.Method:21adult China white rabbits,weigh 2 5~3 5kg,were divided into 3 groups.In group A,7 rabbits were given 100μg/kg of endotoxin from Escherichia intravenously 2 times at an interval of 24 hours,and injected intramuscularly with 20 mg/kg of methylprednisolone 3 times at intervals of 24 hours after the second injection of endotoxin.In group B,10 rabbits were given 20mg/kg of methylprednisolone intramuscularly 3 times at intervals of 24 hours.In group C,4 rabbits were used as the control.Results:The decrease of platelet levels in group A with endotoxin administration after 1,2 and 3 days was more prominent than that in group B without endotoxin treatment( P <0 01).The prolong of coagulate time in group A after 3 days was more prominent than that in group B( P <0 01)。Conclusion:steroid appeared to potentate the coagulate state and systemic coagulation is the important link in steroid induced necrosis of femoral head.
出处 《中国矫形外科杂志》 CAS CSCD 1999年第12期914-916,共3页 Orthopedic Journal of China
基金 内蒙古自治区自然科学基金! 971 30 3 - 1 (0 6)
关键词 诱导 激素性 凝血指标 股骨头缺血坏死 动物模型 ConagulationSteroidOsteonecrosisFemoral head
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  • 1刘万林 郭文通 等.激素性股骨头缺血性坏死动物模型的诱导[J].内蒙古医学院学报,1998,2(20):71-71.

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