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陈兰花冲剂对糖尿病足大鼠血清TNF-α、IL-6、CRP的影响 被引量:13

Effect of Chenlanhua Chongji on Serum TNF-α,IL-6,CRP of Diabetic Foot Rat
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摘要 目的研究陈兰花冲剂对糖尿病足大鼠炎性因子的影响。方法采用腹腔注射STZ,足部注射真菌菌液方法复制大鼠糖尿病足模型。采用ELISA法、液相免疫沉淀散射比浊终点法观察陈兰花冲剂对大鼠血清炎性因子的影响。结果陈兰花冲剂可降低大鼠血清CRP、IL-6、TNF-α炎性因子的水平。结论本实验初步证明了糖尿病足的炎症发生机制以及陈兰花冲剂的抗炎作用。 Objective To study the effect of Chenlanhua chongji on inflammatory cytokines of diabetic foot rat Methods Diabetic rat models were established by abdomen injection of STZ,then fungi were injected into rat digits and diabetic foot models were copied. The effect of Chenlanhua chongji on rat serum inflammatory cytokines level was observed by the method of ELISA. Results CRP, IL - 6,TNF - α were degraded by Chenlanhua chongji. Conclusion This experiment tested the inflammatory mechanism of diabetic foot and the effect of Chenlanhua chongji on restraining inflammation.
出处 《医学研究杂志》 2011年第8期114-118,共5页 Journal of Medical Research
关键词 陈兰花冲剂 糖尿病足 炎症机制 实验研究 Chenlanhua chongji Diabetic foot Inflammatory mechanism Experimental study
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  • 1Amer P.Insulin resistance in type 2 diabetes-role of the ndipokines.Curt Mol Med,2005,5:333.
  • 2Knobler H,Bendedy M,Boyko V,et al.Adipenectien and the development of diabetes in patients with coronary artery disease and impaired fasting glucose.Eur J Endocrinsl,2006,154:87.
  • 3Minoru I,Eisuke M,Maaaa Y,eta/.Correlation between the ndiponectin-leptin ratio and parameters of insulin resistance in patients with type2 diabetes.Metab Clin Exp,2005,54:281.
  • 4Hmciar J,Garbor D,Hrnciarova M,et al.Re]allen between cytokine (TNF-alpha,IL-6 and IL-1) and homocysteine in android obesity and the phenomenon of insulin resistance syndrome.Vnitr Lek,1999,45:11.
  • 5Senn JJ,Klover PJ,Nowak IA,et al.Interlenkin-6 induces cellular insulin resistance in hepatocytes.Diabetes,2002,51:3391.
  • 6Fasshauer M,Kralish S,Klier M,et al.Adipenectin gone expression and secretion is inhlhited by interlenkin-6 in 313-L1 adipocytes.Biochem Biophys Res Commun,2003,301:1045.
  • 7Ouchi N,Kihara S,Arim Y,et al.Adiponetin,an ndipocytederived plasma protein,inhibits endothelial NF-kappaB signaling through a CAMP-dependent way.Circulation,2000,102:1296.
  • 8Reaven GM. Role of insulin resistance in human disease [J].Diabetes, 1998.
  • 9Kershaw EE,Flier J S. Adipose tissue as an endocrine organ[J].J Clin Endocrinol Metab,2004.
  • 10Ookuma M,Ookuma K, York DA, et al. Effects of leptin on insulin secretion from isolated rat pancreaticislets[J]. Diabetes,1998.

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