肝硬化时血清神经肽Y与透明质酸和前胶原蛋白Ⅲ水平变化及临床意义

Clinical value and measurement of serum NPY,HA and PⅢP in patients with liver cirrhosis

目的探讨肝硬化患者血清神经肽Y(NPY)、透明质酸(HA)和前胶原蛋白Ⅲ(PⅢP)水平的变化及临床意义。方法应用放射免疫分析法检测66例肝硬化患者血清NPY、HA和PⅢP水平,并与35例健康对照者作比较。结果肝硬化患者血清NPY水平显著低于健康对照组,差异有统计学意义(P<0.01);而HA和PⅢP水平显著高于健康对照组,且NPY与HA、PⅢP呈明显负相关,差异有统计学意义(r=-0.968 6、-0.955 3,P<0.01)。结论检测肝硬化患者血清NPY、HA和PⅢP水平变化,对了解病情和判断愈后有十分重要的临床价值。

Objective To investigate the levels of serum neuropeptide Y （NPY） and hyaluronic acid（HA） and precollagen type Ⅲ （PⅢP） and their clinical significance in the patients with liver cirrhosis. Methods Serum NPY, HA and PⅢP levels in 66 patients with liver cirrhosis and 35 healthy controls were measured by radioimmunoassay （RIA）. Results The serum NPY levels in the patients were significantly lower than those in the controls（P〈0.01） ,while the serum HA and PⅢP levels in the patients were significantly higher than those in the controls（P〈0.01）. Serum NPY levels were negatively correlated with HA and PⅢP levels in the patients （r =-0. 968 6, =0. 955 3,P〈0.01）. Conclusion Detecting serum NPY, HA and PⅢP levels has important significance to understand the disease condition and judge the prognosis of liver cirrhosis.