3,5-二碘水杨醛缩水杨酰肼Schiff碱及其金属配合物的合成与抑菌活性

Synthesis and Antibacterial Activity of Its Metal Complexes of Salicyhydrazide and 3,5-Diiodo-salicylalidehyde Schiff Base

以吡啶、DMF为溶剂合成了3,5-二碘水杨醛缩水杨酰肼Schiff碱的过渡金属配合物,用紫外可见光谱、红外光谱、TG-DTA、元素分析及摩尔电导率对配合物进行了表征,推测了配合物的可能结构,并对结构特征进行了分析。应用紫外光谱和荧光光谱测定方法研究了配合物与ct-DNA的作用,发现这些配合物均以插入方式与ct-DNA作用。另外,对各配合物作了活性测试,发现它们对阴离子超氧自由基O2-.和藤黄微球菌有良好的抑制作用。

Four coordination compounds of transition metal with 3,5-diiodo-salicylalidehyde and salicyhydrazide Schiff base have been synthesized in pyridine and DMF solvents.These ligand and complexes were characterized by UV and IR spectra,TG-DTG,elemental analysis,and molar conductance analysis.The interactions of the complexes with DNA were investigated by UV and fluorescence spectroscopies,which show that the binding mode of the complexes with ct-DNA was intercalation.In addition,the biological activity test reveals that the complexes have potentially catalytic and antibacterial activity towards superoxide anion radical O-·2 and Micrococcus luteus.