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通心络胶囊联合依那普利对慢性肺心病患者心功能影响的临床研究 被引量:1

Clinical Study of Tongxinluo Capsule Combined with Enalapril Improving Right Ventricular Function of Patients with Chronic Pulmonary Heart Disease
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摘要 目的观察通心络胶囊联合依那普利对慢性肺源性心脏病右心功能的影响。方法选择我院符合标准的肺心病患者105例,随机分为治疗组和对照组:对照组(42例)常规治疗;治疗组(63例)加用通心络胶囊联合依那普利。观察两组治疗后心功能,检测治疗前、后右心功能[舒张早期血流速度峰值(VE)、舒张末期血流速度峰值(VA)、舒张末期血流速度峰值/舒张早期血流速度峰值(VA/VE)、肺动脉收缩压(SPAP)、左室射血前期时间(PEP)、右室射血时间(RVET)、左室射血前期时间/右室射血时间(PEP/RVET)],检测动脉血气分析指标的变化。结果两组患者的总有效率间差异有统计学意义(P<0.01)。治疗组患者治疗前后VE、VA、VA/VE、SPAP、PEP、RVET及PEP/RVET、血气分析各指标间差异均有统计学意义(P<0.01),两组患者治疗后VE、VA、VA/VE、SPAP、PEP、RVET及PEP/RVET、血气分析各指标间差异均有统计学意义(P<0.01)。结论通心络胶囊联合依那普利可以降低慢性肺心病患者肺动脉压,提高患者的右心功能,是治疗慢性肺源性心脏病右心功能不全的有效药物。 Objective To observe the effect of tongxinluo capsule combined with enalapril improving right ventricular function of patients with chronic pulmonary heart disease(CPHD).Methods 105 patients with CPHD selected were randomly divided into group,cure group and control.the control group(42 cases)was given routine therapy,the cure group(63 cases)was given tongxinluo capsule combined with enalapril on the basis of the therapy of the control group.The clinical effect of the two groups was observed after treatment.Right ventricular function(A peak,E peak,VA/VE,SPAP,PEP,RVET,PEP/RVET)was detected before and after treament;the blood gas analysis was done before and after treament.Results The total effective rate(90.4% )in the cure group was significantly higher than that in the control group (78.5%)(P〈0.01); cardiac function and the other laboratory indexes in the cure group were all superior to those in the control group (P〈0.01).Conclusion Tongxinluo capsule combined with enalapril can decrease the pulmonary artery pressure,improve the right ventricular function and is an effective drug for improving right vent ricular function in CPHD patients.
作者 李香玉
出处 《临床合理用药杂志》 2011年第01X期28-29,31,共3页 Chinese Journal of Clinical Rational Drug Use
关键词 慢性肺源性心脏病 右心功能 通心络胶囊 依那普利 Chronic pulmonary heart disease Right vent ricular function Tongxinluo capsule Enalapril
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