清热燥湿法治疗湿热型溃疡性结肠炎临床观察

Clinical Observation of Method of Clearing Away Heat to Make Dampness Dry on Ulcerative Colitis(with Syndrome of Large Intestine Damp-heat)

目的:观察清热燥湿法治疗溃疡性结肠炎(大肠湿热型)的有效性和安全性。方法:选溃疡性结肠炎(大肠湿热型)患者160例,随机分为两组。治疗组83例,采用清热燥湿法中药汤剂;对照组77例,口服柳氮磺胺吡啶片。治疗4周后观察患者症状变化及内镜检查情况。结果:治疗组治愈16例,显效30例,有效24例,无效13例,总有效率为84.3%(95%CI=76.5%～92.1%);对照组治愈12例,显效16例,有效28例,无效21例,总有效率为72.7%(95%CI=62.8%～82.7%);两组综合疗效比较(u=2.147 8,P=0.031 9),差异有显著性意义。结论:清热燥湿法治疗溃疡性结肠炎(大肠湿热型)疗效优于柳氮磺胺吡啶,其收益为OR=0.50(95%CI=0.23～1.08),NNT=9(95%CI=4.12～101.20)。

To observe the curative efficacy and safety of method of clearing away heat to make dampness dry on ulcerative colitis with the syndrome of large intestine damp -heat. Methods： 160 cases with ulcerative colitis with the syndrome of large intestine damp - heat were divided into two groups randomly. 83 cases in treatment group were treated with TCM decoction, and 77 ones in control group were done with sulfasalazine. After 4 weeks the symptoms and endoscopic examination were observed. Results： In treatment group 16 cases were recovered, 30 ones excellent, 24 ones effective, 13 ones ineffective. The total effective rate was 84. 3% （95% CI = 76. 5% - 92. 1% ）. In control group 12 cases were recovered, 16 ones excellent, 28 ones effective, 21 ones ineffective. The total effective rate was 72.7% （95% CI =62. 8% - 82. 7% ）. There was significant difference between the two groups （u = 2. 1478, P = 0. 0319）. Conclusion： The effect of method of clearing away heat to make dampness dry is better than that of sulfasalazine on ulcerative colitis with the syndrome of large intestine damp - heat, OR =0. 50 （95%CI =0. 23 - 1.08） NNT =9 （95%CI =4. 12- 101.20）.