米非司酮联合米索前列醇与依沙吖啶对中期妊娠引产的效果探讨

The effectiveness of Mifepristone combined with Misoprostol and Ethacridine to terminating of second trimester pregnancy

目的探讨两种不同方法对中期妊娠引产的临床效果。方法将120例中期妊娠引产对象随机分为观察组和对照组,每组60例。观察组采用米非司酮联合米索前列醇引产;对照组常规依沙吖啶羊膜腔内注射,比较两组引产效果。结果观察组比对照组宫颈成熟度好,宫缩发动时间明显提前,产程短,清宫率低,出血量少,排出时间缩短,差异有统计学意义(P<0.05);引产成功率两组间相比差异无统计学意义(P>0.05)。观察组胃肠道反应高于对照组,对照组有1例宫颈裂伤。结论米非司酮联合米索前列醇引产简单、安全、高效,引产后不需常规清宫,创伤性小,明显优于传统的依沙吖啶引产,值得临床推广。

Objective To investigate the clinical effectiveness of two different methods in termination of second trimester pregnancy. Methods 120 cases of the termination of second trimester pregnancy were divided randomly into observing group and control group, 60 cases for each.observing group was treated with Mifepristone and misoprostol,control group was treated with amniotic cavity injection of Ethacridine.The clinical effectiveness of two methods was evaluated. Results Compared with control group,better cervical maturity,shorter duration of labour induction,lower rate of post-abortion curettage,less amount of vaginal bleeding and less time of transpiration were founded in observing group（P0.05）.There was statistics significant difference respectively （Pall 0.05）.There were no significant differences in the clinical effectiveness between two groups（P0.05）.Gastrointestinal tract obsering group was higher than the control group, l case of cervical laceration.Conclusion Mifepristone combined with Misoprostol used for labour induction is superior to traditional amniotic cavity injection of rivanol for its easy operation,safe, effective,no need of curettage after induced abortion and less traumatic,it is worthy of clinical application.