头孢哌酮钠及其复方制剂中的有关物质分析

Analysis on the related substances in cefoperazone sodium and its compound preparations

头孢哌酮钠为第三代头孢菌素类抗生素,临床用于治疗各种细菌感染性疾病;其复方制剂有头孢哌酮钠舒巴坦钠和头孢哌酮钠他唑巴坦钠,主要用于产β-内酰胺酶耐药菌感染的治疗。国内外研究表明,它们的不良反应与其所含有关物质密切相关。本文将对头孢哌酮钠及其复方制剂有关物质的来源、化学结构、分析方法以及国内外限量标准等研究内容进行综述,为控制有关物质含量,减少不良反应提供指导意义。

Cefoperazone sodium was one of the third generation cephalosporin antibiotics,usually be used for the treatment of various infections.Cefoperazone sodium/sulbactam sodium and cefoperazone sodium/tazobactam sodium are the compound preparations of cefoperazone,they are used to against the infection of β-lactamase-producing pathogenic strains.Researchers generally considered that the major adverse drug reactions of cephalosporins are closely related to the related substances in drugs.This review mainly focuses on the research progress of the related substances in cefoperazone sodium and its compound preparations,including the sources,chemical structures,analytical methods,as well as limited standards domestic and abroad,in order to provide some reference to lower the incidence of adverse reactions.