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慢性乙型肝炎及肝硬化患者血清HBVPreS1-Ag、HBV-DNA、HBeAg之间的关系分析 被引量:3

慢性乙型肝炎及肝硬化患者血清HBV PreS1-Ag、HBV-DNA、HBeAg之间的关系分析
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摘要 目的探讨慢性乙型肝炎及肝硬化患者血清HBVPreS1-Ag、HBV-DNA、HBeAg之间的相关性及意义。方法对6O例慢性乙型肝炎及肝硬化患者进行回顾性分析,均为HBsAg阳性,采用实时荧光定量聚合酶链反应、化学发光法及全自动酶免仪分别检测患者血清HBV-DNA、HBeAg及HBVPreS1-Ag。结果 6O例HBsAg阳性慢性乙型肝炎及肝硬化患者中,HBVPreS1-Ag的检出率为58.33%,HBV-DNA的检出率为61.67%,HBeAg的检出率为33.3%。HBVPreS1-Ag、HBV-DNA的检出率明显高于HBeAg的检出率,差异有统计学意义(P<O.O5);HBVPreS1-Ag与HBV-DNA的检出率相近,差异无统计学意义(P>O.05)。结论 HBVPreS1-Ag与HBV-DNA在慢性乙肝及肝硬化患者血清中有相似的检出率,在反映慢性乙型肝炎及肝硬化患者血液中HBV的复制情况时,更加显著。 Objective Discussion chronic second grade hepatitis and between liver cirrhosis patient blood serum HBV PreS1-Ag, HBV-DNA, HBeAg relevance and significance. Methods Carry on the review analysis to the 60 example chronic second grade hepatitis and liver cirrhosis patient, is the HBsAg masculine gender, uses the real-time fluorescence quota polymerase chain reaction, the chemiluminescence law and the completely automatic enzyme exempts the meter to examine patient blood serum HBV-DNA, HBeAg and HBV PreS1-Ag separately. Results 60 in the example HBsAg masculine gender chronic second grade hepatitis and liver cirrhosis patient, HBV PreS 1-Ag picks out rate is 58.33%, HBV-DNA picks out rate is 61.67%, HBeAg picks out rate is 33.3%.HBV PreS 1-Ag, HBV-DNA pick out rate are higher than HBeAg to pick out obviously rate, the difference has statistics significance (P〈0.05); HBV PreS 1-Ag and HBV-DNA pick out rate are close, difference non-statistics significance (P〉0.05).Conclusion HBV PreS 1-Ag and HBV-DNA have similarly at the chronic hepatitis B and in liver cirrhosis patient blood serum pick out rate, when reflection chronic second grade hepatitis and liver cirrhosis patient blood HBV duplication situation, more remarkable.
作者 范英华
出处 《当代医学》 2011年第29期16-18,共3页 Contemporary Medicine
关键词 慢性乙型肝炎 肝硬化 HBVPreS1一Ag HBV-DNA HBEAG Chronic second grade hepatitis Liver cirrhosis HBV PreS 1-Ag HBV-DNA HBeAg
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