摘要
目的探讨慢性乙型肝炎及肝硬化患者血清HBVPreS1-Ag、HBV-DNA、HBeAg之间的相关性及意义。方法对6O例慢性乙型肝炎及肝硬化患者进行回顾性分析,均为HBsAg阳性,采用实时荧光定量聚合酶链反应、化学发光法及全自动酶免仪分别检测患者血清HBV-DNA、HBeAg及HBVPreS1-Ag。结果 6O例HBsAg阳性慢性乙型肝炎及肝硬化患者中,HBVPreS1-Ag的检出率为58.33%,HBV-DNA的检出率为61.67%,HBeAg的检出率为33.3%。HBVPreS1-Ag、HBV-DNA的检出率明显高于HBeAg的检出率,差异有统计学意义(P<O.O5);HBVPreS1-Ag与HBV-DNA的检出率相近,差异无统计学意义(P>O.05)。结论 HBVPreS1-Ag与HBV-DNA在慢性乙肝及肝硬化患者血清中有相似的检出率,在反映慢性乙型肝炎及肝硬化患者血液中HBV的复制情况时,更加显著。
Objective Discussion chronic second grade hepatitis and between liver cirrhosis patient blood serum HBV PreS1-Ag, HBV-DNA, HBeAg relevance and significance. Methods Carry on the review analysis to the 60 example chronic second grade hepatitis and liver cirrhosis patient, is the HBsAg masculine gender, uses the real-time fluorescence quota polymerase chain reaction, the chemiluminescence law and the completely automatic enzyme exempts the meter to examine patient blood serum HBV-DNA, HBeAg and HBV PreS1-Ag separately. Results 60 in the example HBsAg masculine gender chronic second grade hepatitis and liver cirrhosis patient, HBV PreS 1-Ag picks out rate is 58.33%, HBV-DNA picks out rate is 61.67%, HBeAg picks out rate is 33.3%.HBV PreS 1-Ag, HBV-DNA pick out rate are higher than HBeAg to pick out obviously rate, the difference has statistics significance (P〈0.05); HBV PreS 1-Ag and HBV-DNA pick out rate are close, difference non-statistics significance (P〉0.05).Conclusion HBV PreS 1-Ag and HBV-DNA have similarly at the chronic hepatitis B and in liver cirrhosis patient blood serum pick out rate, when reflection chronic second grade hepatitis and liver cirrhosis patient blood HBV duplication situation, more remarkable.
出处
《当代医学》
2011年第29期16-18,共3页
Contemporary Medicine