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Her-2表达情况对ER/PR阴性乳腺癌预后的影响

Analysis of the relationship between the state of her-2 and the prognosis of er and pr negative breast cancer in china and the risk factors
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摘要 目的分析ER/PR阴性乳腺癌患者的临床资料,探讨Her-2表达与否对ER/PR阴性乳腺癌预后的影响。方法运用Kaplan-Meier检验及Cox回归分析对我病房2007～2008年的171例ER/PR阴性乳腺癌患者的临床资料进行分析,分析探讨Her-2表达情况对ER/PR阴性乳腺癌的预后影响及相关危险因素。结果截至2011年2月,随访时间为37～51个月,中位随访时间32个月,三阴性乳腺癌与ER/PR阴性、Her-2阳性乳腺癌经过CEF方案辅助化疗后的无复发生存期分别为3.269+0.626年及3.271+0.997年,无明显差异(P>0.05);两组总生存时间分别为3.490+0.286年及3.611+0.722年,无明显差异(P>0.05);对年龄、Her-2表达及淋巴转移等因素进一步分析显示年龄及Her-2表达情况对复发无明显影响(P>0.05);淋巴转移与否是乳腺癌复发转移的独立影响因素(P<0.05)。结论三阴性乳腺癌并非较ER/PR阴性、Her-2阳性乳腺癌更高危,但淋巴结的转移情况是ER/PR阴性乳腺癌复发的独立影响因素,因而进行早期的淋巴结筛查有重要意义。 【Objective】 To analysis of the relationship between the state of Her-2 and the prognosis of ER and PR negative breast cancer in China and the risk factors.【Methods】 The clinical data of the ER and PR negative breast cancer patients who underwent treatment in our department from 2007 to 2008 was collected,the patients was 171 case.The relationship between the State of Her-2 and the Prognosis of ER and PR Negative Breast Cancer and the risk factors of the ER and PR negative breast cancer was analyzed by Kaplan-Meier and Cox analysis.【Results】 The ER and PR negative breast cancer is not related with age,the state of Her-2,but it is Significantly related with the number of axillary metastatic lymph node（P0.05）.【Conclusion】 The number of axillary metastatic lymph node is one of the risk factors influencing the incidence of breast cancer among Chinese female,and the prognosis of the triple negative breast cancer（TNBC） is not different from the ER and PR negative breast cancer.
作者 李凯 李午生 谭永刚 赵力 邹华伟
机构地区 中国医科大学附属盛京医院肿瘤科
出处 《中国医学工程》 2011年第8期26-27,29,共3页 China Medical Engineering
基金 辽宁省教育厅课题(2007CB512702)
关键词 三阴乳腺癌 HER-2表达 ER阴性 PR阴性 危险因素 TNBC the state of Her-2 ER negative PR negative risk factors
分类号 R737.9 [医药卫生—肿瘤]
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参考文献8

  • 1Dent R, Trudeau M, Pritchard KJ, et al. Triple negative breast cancer: features and patterns of recurrence [ J ]. Clin Cancer Res, 2007, 13(15) : 4429 -4434.
  • 2Rakha EA, EI - Sayed ME, Green AR, et al. Prognostic markers in triple negative breast cancer[ J]. Cancer, 2007, 109 ( 1 ) :25 -32.
  • 3Umemura S, Takekoshi S, Suzuki Y, et al. Estrogen receptor- negative and human epidermal growth factor receptor 2 - negative breast cancer tissue have the highest Ki - 67 labeling index and EGFR expression: gene amplification does not contribute to EGFR expression[ J ]. Oncol Rep, 2005,14 (2) : 337 - 343.
  • 4Bryan BB, Schnitt S J, Collins LC. Ductal carcinoma in situ with basal - like phenotype : apossible precursor to invasive basal - like breast cancer [ J ]. Mod Pathol,2006 ; 19 (5) :617.
  • 5Bauer KR, Brown M, Cress RD, et al. Descriptive analysis of es- trogen receptor ( ER ) - negative, progesterone receptor ( PR ) - negative, and HER- negative in vasive breast cancer, thesocalled triple - negative phenotype : apopulation based study from the Cali- fornia cancer Registry[J]. Cancer,2007,109(9) :1721.
  • 6Dent R, Trudeau M, Pritchard KI, et al. Triple - negative breast cancer: clinical features and patterns of recurrence [ J ]. Clin Canc- er Res ,2007,13 ( 15Pt1) :4429.
  • 7袁中玉,王树森,高岩,苏争艳,罗文标,管忠震.305例三阴乳腺癌患者的临床特征及预后因素分析[J].癌症,2008,27(6):561-565. 被引量：161
  • 8Liedtke C, Mazouni C, Hess KR, et al. Response to neoadjuvant therapy and long - term survival in patients with triple - negative breast cancer[ J]. JClin Oncol,2008 ;26 ( 8 ) B1275.

二级参考文献19

  • 1Perou C M, Sorlie T, Eisen M-B, et al. Molecular portraits of human breast tumors [J]. Nature, 2000,406(6797) :747-752.
  • 2van't Veer L J, Dai H, van de Vijver M J, et al. Gene expression profiling predicts clinical outcome of breast cancer [J ]. Nature, 2002,415(6871 ) : 530-536.
  • 3Sotiriou C, Neo S Y, McShane L M, et al. Breast cancer classification and prognosis based on gene expression profiles from a population based study [J]. Proc Natl Acad Sci USA, 2003,100(18) : 10393-10398.
  • 4Rakha E A, El-Sayed M E, Green A R, et al. Prognostic markers in triple-negative breast cancer [J]. Cancer, 2007, 109( 1 ) : 25-32.
  • 5Jones C, Nonni A V, Fulford L, et al. CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation [ J ]. Br J Cancer, 2001,85 ( 3 ) : 422-427.
  • 6Nielsen T O, Hsu F D, Jensen K, et al. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma [J]. Clin Cancer Res, 2004, 10 (16) :5367-5374.
  • 7Banerjee S, Reis-Filho J S, Ashley S, et al. Basal-like breast carcinomas: clinical outcome and response to chemotherapy [J]. J Clin Pathol, 2006,59(7):729-735.
  • 8Carey L A, Dees E C, Sawyer L, et al. The triple negative paradox : primary tumor chemosensitivity of breast cancer subtypes [J]. Clin Cancer Res, 2007,13(8) :2329-2334.
  • 9Chu K C, Lamar C A, Freeman H P. Racial disparities in breast carcinoma survival rates: separating factors that affect diagnosis from factors that affect treatment [J]. Cancer, 2003, 97( 11 ) : 2853-2860.
  • 10Cunningham J E, Butler W M. Racial disparities in female breast cancer in South Carolina: clinical evidence for a biological basis [ J ]. Breast Cancer Res Treat, 2004,88 (2) : 161-176.

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中国医学工程
2011年 第8期

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