关节置换术后感染的治疗

Treatment of infection after joint replacement

膝和髋关节置换术后2年内感染风险最高。感染的主要致病菌为G＋球菌，以金黄色葡萄球菌、表皮葡萄球菌最常见；诊断时应正确获取标本，关注ESR、CRP、影像学等实验室指标；临床治疗时常用二期假体置换术并用抗生素治疗6。8周：在抗生素治疗过程中，临床药师发挥专业优势，根据患者的年龄、肝肾功能、感染的致病茵选择合理的抗生素，为患者提供个体化的治疗方案，并在患者出院时做好用药教育，提高患者用药的依从性，从而取得良好的治疗效果。

The highest infection risk in knee and hip replacement surgery occur within two years. The main pathogenic bacterium of infection is G＋ cocci including staphylococcus aureus, staphylococcus epidermidis. It is important to obtain proper specimens and monitor ESR, CRP, iconography and other laboratory parameters. The common treatment is the second stage of revision with infection of prosthetic replacement and combination with antibiotic therapy for 6-8 weeks. Clinical pharmacists exert preponderance during antibiotic therapy. They select the proper antibiotic for patients and design individualized treatment programs according to the age, renal function and pathogen of the patients. They also provide pharmaceutical service when patients discharge from the hospital, which improves compliance of drug use and obtains good therapeutic effect.