功能磁共振成像在下肢骨骼肌缺血损伤中的应用

The application of functional MRI in evaluating ischemic injuries of lower limb skeletal muscle

下肢骨骼肌缺血损伤是由于各种原因引起肢体动脉供血不足以致肌组织缺血、缺氧的变化,评估骨骼肌缺血损伤的程度对下肢缺血性疾病的治疗、疗效评价和预后有指导作用。随着扫描软硬件的不断提升更新,弥散加权成像(DWI)、扩散张量成像(DTI)、灌注加权成像(PWI)、血氧饱和水平依赖(BOLD)、磁共振波谱分析(MRS)等新技术的出现,也彻底改变了MRI在临床以及科研中的应用价值,其能更深入的反映组织生理结构及病理学改变。本文主要针对这些技术在下肢骨骼肌缺血损伤中的应用作一综述。

The ischemic injury of lower limb skeletal muscle is caused by various reasons that lead to limb arterial blood flow insufficiency and subsequent muscle tissue hypoxia.Exact and correct evaluation of the ischemic degree of the skeletal muscle is very important for the physicians to guide the clinical treatment,to assess the therapeutic effect and to judge the prognosis.With the development and updating of scanning hardware and software,together with the use of diffusion-weighted imaging（DWI）,diffusion tensor imaging（DTI）,perfusion-weighted imaging（PWI）,blood oxygen level dependent（BOLD） imaging and magnetic resonance spectroscopy（MRS）,etc.the application of MRI has been dramatically expanded both in clinical practice and scientific researches.Nowadays,functional MRI can accurately reflect the physiological structures and pathologic changes in detail.This article aims mainly to make a comprehensive review about the application of these techniques in assessing the ischemic injuries of lower limb skeletal muscle.