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血浆GLP-1水平对糖尿病胃轻瘫病人固体胃排空影响 被引量:6

EFFECT OF GLP-1 ON SOLID GASTRIC EMPTYING IN PATIENTS WITH DIABETES GASTROPARESIS
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摘要 目的探讨糖尿病胃轻瘫(DGP)病人血浆胰高糖素样肽-1(GLP-1)水平对固体胃排空的影响。方法应用放射性核素法对55例2型糖尿病病人及15例正常人(NC组)进行固体胃半排空时间(T1/2)测定。根据T1/2结果将糖尿病病人分为胃排空时间正常的DM组和胃排空延迟的DGP组。采用酶联免疫吸附法检测各组空腹及餐后301、20 min血浆GLP-1水平。结果与NC组相比,DM组空腹及餐后30 min血浆GLP-1水平降低(F=37.202、108.304,q=2.933、3.654,P<0.05),餐后120 min血浆GLP-1水平及T1/2差异无显著性。与NC组、DM组相比,DGP组空腹及餐后30 min血浆GLP-1水平明显升高(q=4.336~14.606,P<0.05),餐后120 min血浆GLP-1水平差异无显著性,胃T1/2延迟(F=61.562,q=7.994、10.585,P<0.05)。DM组空腹及餐后30 min血浆GLP-1水平与胃T1/2无相关性,DGP组空腹及餐后30 min血浆GLP-1水平与胃T1/2呈正相关(r=0.482、0.560,P<0.05)。结论 DGP病人胃排空延迟可能与空腹及餐后30 min血浆GLP-1水平升高有关。 Objective To investigate the influence of plasma level of glucagon-like peptide-1(GLP-1) on solid gastric emptying in patients with diabetes gastroparesis(DGP). Methods Using radioactive nuclide technique,solid gastric half-emptying time(T1/2) in 55 patients with type 2 diabetes and 15 health adults were measured.According to the T1/2 results,the patients were divided into normal gastric emptying(DE) group and DGP group.The plasma levels of GLP-1 in all subjects were measured by enzyme-linked immunosorbent assay at fasting and 30 min and 120 min after meals. Results Compared with the normal control,the fasting GLP-1 level and that 30 min after meals in DM group declined(F=37.202,108.304;q=2.933,3.654;P0.05);but that 120 min after meals and T1/2 showed no statistical differences between the two groups;Compared with normal control and DM group,GLP-1 levels at fasting and 30 min after meals in DGP group increased obviously(q=4.336-14.606,P0.05),GLP-1 levels at 120 min after meals had no statistical differences,T1/2 significantly delayed(F=61.562;q=7.994,10.585;P0.05).In DM group,fasting GLP-1 and that 30 min after meals were not correlated with T1/2;In DGP group,the GLP-1 levels at fasting and 30 min after meals were positively correlated with T1/2(r=0.482,0.560;P0.05).Conclusion Delayed gastric emptying in DGP patients is likely to be associated with elevation of fasting plasma levels of GLP-1 and that 30 min after meals.
出处 《青岛大学医学院学报》 CAS 2011年第4期324-326,328,共4页 Acta Academiae Medicinae Qingdao Universitatis
基金 山东省自然科学基金资助项目(ZR2009CM105)
关键词 糖尿病并发症 胃肌轻瘫 胰高血糖素样肽1 胃排空 diabetic complication gastroparesis glucagon-like peptide 1 gastric emptying
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