生长抑素对人Oddi括约肌机能性的影响

THE EFFECT OF OCTROTIDE ON THE MOTILITYOF SPHINCTER OF ODDI IN HUMANS

通过内镜下Ｏｄｄｉ括约肌压力测定的方法，观察了皮下注射生长抑素（ｏｃｔｒｅｏｔｉｄｅ）后对人Ｏｄｄｉ括约肌机能性的影响。发现ｏｃｔｒｅｏｔｉｄｅ能显著升高人Ｏｄｄｉ括约肌基础压从４２．３±１０．５上升到７１±９．４ｍｍＨｇ（５．６３±１．４及９．４４±１．２５ｋＰａ，Ｐ＜０．０１），和括约肌时相收缩频率（从５．６±１０次／分上升到８．６±１．７次／分，Ｐ＜０．０１），时相收缩振幅无明显变化（ｐ＝０．１４）。该结果提示，ｏｃｔｒｅｏｔｉｄｅ能兴奋人Ｏｄｄｉ括约肌，导致胆汁流出受阻。

Using endoscopic manometry of sphincter of Oddi in humans, we observed the effect of Octreotide administered subcutaneously on the motility of sphincter of Oddi. The results showed that Octreotide increased the basal pressure of sphincter of Oddi from 42.3±10.5 to 71 ±9.4mmHg (P<0.01) and the frequency of phasic contraction from 5.6±1.0 to 8.6±1.7 contractions/min(P<0.01). There was no significant change in the amplitude of phasic contraction(P=0. 14). Our conclusion was that Octreotide had an exitatory effect of human sphincter of Oddi, which resulted in the increase of resistance of bile outflow.