摘要
山麦冬总皂甙600mg/kg ip明显降低小鼠自发活动数,并可显著对抗苯甲酸钠咖啡因所致的运动性兴奋。450mg,600mg及900mg/kg分别可加强戊巴比妥钠的催眠作用、增强氯丙嗪的中枢抑制作用及哌替啶的镇痛作用,但本品无明显的催眠作用及抗惊厥作用。
The results showed that TSL 600mg/kg ip decreased obviously spontaneous activity of mice. The same dose of TSL opposed significantly excited conditions induced by CNB. TSL 450mg/kg ip potentiated the hypnoticaction of subthreshould dose of sodium pentobarbital to produce hypnosis.TSL 600mg/kg ip enhanced obviously sedative action of subthreshould dose of chlorpromazine. TSL 900mg/kg ip augmented remarkably the analgesic action of subthreshould dose of pethidine. These results indicated that TSL has a well sedative action and the synergism between TSL and drugs inhibiting CNS is well existed.
出处
《中药药理与临床》
CAS
CSCD
1990年第1期35-37,共3页
Pharmacology and Clinics of Chinese Materia Medica
关键词
山麦冬总皂甙
中枢抑制作用
Total saponins of Liriope spicata Lcur, Sedative action, Synergizm
