摘要
A rat model was used to explore the therapeutic effects of ginsenosides (GS)on smoke inhalation long injury.It was found that GS could markedly alleviate the in-crease of pulmonary microvascular permeability (PMVP),reduction of protein and leu-cocyte content in the bronchoalveolar lavage fluid (BALF) of the smoke inhalation injur-ed rats.Histopathological studies of the lungs revealed that GS could distinctly reduceleucocyte accumulation in the vessels,interstitial infiltration of leucocytes,interstitial andintra-alveolar edema,hemorrhage and vascular congestion.Meanwhile,GS could inhibitthe elevation of malondialdehyde (MDA) in the lungs and serum and reverse the decrea-sed activity of superoxide dismutase (SOD) in the lungs after smoke inhalation.In addi-tion experiments in vitro also showed the inhibition of lipid peroxidation in lung homo-genate and elimination of superoxide anions hydroxyl radicals effectively by GS in properdoses.These results imply that there is close interrelationship between the therapeuticefficiency of GS on smoke inhalation lung injury and its capability of antioxidation.
A rat model was used to explore the therapeutic effects of ginsenosides (GS) on smoke inhalation long injury.It was found that GS could markedly alleviate the in- crease of pulmonary microvascular permeability (PMVP),reduction of protein and leu- cocyte content in the bronchoalveolar lavage fluid (BALF) of the smoke inhalation injur- ed rats.Histopathological studies of the lungs revealed that GS could distinctly reduce leucocyte accumulation in the vessels,interstitial infiltration of leucocytes,interstitial and intra-alveolar edema,hemorrhage and vascular congestion.Meanwhile,GS could inhibit the elevation of malondialdehyde (MDA) in the lungs and serum and reverse the decrea- sed activity of superoxide dismutase (SOD) in the lungs after smoke inhalation.In addi- tion experiments in vitro also showed the inhibition of lipid peroxidation in lung homo- genate and elimination of superoxide anions hydroxyl radicals effectively by GS in proper doses.These results imply that there is close interrelationship between the therapeutic efficiency of GS on smoke inhalation lung injury and its capability of antioxidation.
