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抗心绞痛药烟浪丁的工艺改进

THE IMPROVED PREPARATION OF THE ANTI-STENOCARDIA DRUG——NICORANDIL SG-75
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摘要 烟浪丁(Nicorandil,SG-75)化学名N-(2-羟乙基)烟酰胺硝酸酯。本品是目前临床上用来治疗冠心病、心绞痛的有效药物。关于本品合成国内外文献报道较多,但综合起来主要有下面A、B两条路线: The improved preparation of nicorandil, SG-75 included esterification of nicotinic acid and nitric acid. The experimental eonditions were greatly changed and its total yield was increased up to 59%. (38.7% in the literature).
出处 《中国药物化学杂志》 CAS CSCD 1990年第1期75-76,共2页 Chinese Journal of Medicinal Chemistry
关键词 anti-stenocardia DRUG nicornadil anti-stenocardia drug nicornadil
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