摘要
烟浪丁(Nicorandil,SG-75)化学名N-(2-羟乙基)烟酰胺硝酸酯。本品是目前临床上用来治疗冠心病、心绞痛的有效药物。关于本品合成国内外文献报道较多,但综合起来主要有下面A、B两条路线:
The improved preparation of nicorandil, SG-75 included esterification of nicotinic acid and nitric acid. The experimental eonditions were greatly changed and its total yield was increased up to 59%. (38.7% in the literature).
出处
《中国药物化学杂志》
CAS
CSCD
1990年第1期75-76,共2页
Chinese Journal of Medicinal Chemistry