摘要
目的分析肝炎标志物阴性的老年肝功能异常患者的病因特点。方法选取年龄≥60岁的肝功能异常患者164例作为老年组,其中肝炎标志物阴性者114例(老年肝炎阴性亚组);另选年龄<60岁的肝功能异常者152例作为非老年组,其中肝炎标志物阴性者90例(非老年肝炎阴性亚组)。比较2组肝功能异常率及2亚组肝功能异常原因。结果老年组肝功能异常发生率为69.51%(114/164),非老年组为59.21%(90/152),2组差异无统计学意义(P>0.05)。老年肝炎阴性亚组以药物性肝损害、胆源性肝损害、肿瘤为病因的发病率高于非老年肝炎阴性亚组,以病毒感染为病因的发病率低于非老年肝炎阳性亚组,差异均有统计学意义(P<0.05)。结论老年肝功能异常由非病毒性肝炎引起者所占比例较高,在病因构成上老年组与中青年无明显差异,但在构成比上有老年人自身的特点。
Objective To discuss the etiological pattern of elderly patients with hepatitis-markers-negative liver dysfunction. Methods 164 cases liver dysfunction patients of the age ~〉60 years were selected as the older group, including hepatitis markers of negative 114 cases( negative hepatitis elderly subgroup) ;152 abnormal liver function patients aged 〈 60 years were selected as the non-elderly group, negative hepatitis markers among 90 cases (hepatitis-negative non-elderly subgroup). Compared the rates of abnormal liver function of the two groups and reasons of abnormal liver function of the two subgroup. Re- suits The incidence of liver dysfunction was 69.51% (114/164) of the older group, and non-elderly group was 59.21% ( 90/152 ), there was no significant difference ( P 〉 0.05 ). Hepatitis-negative subgroup of elderly with drug induced liver injury, liver injury in bile source, a high incidence of cancer as the cause of the hepatitis-negative non-elderly subgroup, the incidence of viral infection as the cause of the hepatitis-positive rate was less than non-elderly subgroup, the difference was statistically significant(P 〈 0.05 ). Conclusion The incidence of hepatitis-markers-negative liver dysfunction in elderly patients were higher. In the constituent of the causes there are no differernce between the two groups. In the constituent ratio of the causes the group of elderly patients has its own feature.
出处
《临床合理用药杂志》
2011年第21期29-30,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
肝功能异常
老年人
病因分析
Liver dysfunction
The elder
Causes of disease