蒙脱石散联合氟康唑治疗霉菌性食道炎的临床研究

Clinical study on Smectite powder combined fluconazole in treatment of patients with mycotic esophagitis

目的探讨蒙脱石散治疗霉菌性食道炎的临床效果和安全性。方法 84例确诊霉菌性食道炎患者随机分为治疗组45例和对照组39例,对照组应用奥美拉唑、莫沙必利和氟康唑治疗,治疗组在对照组治疗基础上加用蒙脱石散治疗。比较2组临床疗效及不良反应发生率。结果治疗组总有效率为100.0%,对照组为94.9%,2组比较差异无统计学意义(P>0.05)。2组不良反应轻微,均未予特殊处理。结论蒙脱石散对霉菌性食管炎有一定的治疗作用,必要时可考虑使用。

Objective To investigate the effectiveness and safety of Smeetite powder for mycotic esophagitis treatment. Methods A total of 84 mycotic esophagitis patients were randomly divided into treatment group （ n = 45 ） and control group（ n = 39）. The control group received omeprazole, mosapride and fluconazole, wihle the treatment group was given with smectite powder on the basis of control group. The efficacy and Clinical efficacy and adverse reaction rates were observed after the treatment. Results The total effect rate in treatment group and control group was 100% and 94.9% respectively, and the difference was not significant（ P 〉 0.05 ）. There were minor adverse reactions in both groups, and no special treatment were given to the two groups. Conclusion Smectite powder may be have some therapic effectiveness for the treatment of mycotic esophagitis, it is not a optimal choice for physicians if necessary.