地佐辛联合帕瑞昔布钠预防全身麻醉苏醒期躁动

Dezocine Combined Parecoxib Prevent of Agitation after General Anesthesia

目的:探讨术中应用地佐辛联合帕瑞昔布钠预防全麻苏醒期躁动的效果。方法:选择ASAⅠ～Ⅱ级全身麻醉下进行开腹胆囊切除术患者75例,随机分为3组,各25例。Ⅰ组给予地佐辛5mg;Ⅱ组给予地佐辛10mg;Ⅲ组给予地佐辛5mg联合帕瑞昔布钠40mg。在手术进行到关腹时静脉给药,观察比较苏醒期三组患者的躁动发生情况、疼痛评分及不良反应(恶心、呕吐等)。结果:Ⅱ组和Ⅲ组患者躁动发生率和疼痛评分均低于Ⅰ组(P<0.05),Ⅱ组和Ⅲ组间差异无显著性(P>0.05)。Ⅲ组不良反应发生率小于Ⅰ组和Ⅱ组(P<0.05)。结论:术中应用地佐辛联合帕瑞昔布钠对预防全麻苏醒期躁动具有良好的效果,并能降低不良反应发生率。

Objective： Investigate the effect of dezocine combined parecoxib prevention of anesthesia gitation. Methods： Se- lect ASA I - II grade under general anesthesia, 90 patients with cholecystectomy, were randomly divided into 3 groups. I group received dezocine 5 mg; II group received sufentanil 10 mg ;III were given f dezocine 5 mg and parecoxib 40 mg. 20 min before the end of surgery they were given by vein. Observe and compare the emergence of three groups of patients the occurrence of agitation, pain score and side effects （nausea, vomiting, etc.） Results： In II and III group the incidence of agitation and pain scores were lower than in group I （P 〈0. 05）. In II and III there was no significant difference （P〉 0. 05）. In III adverse reaction rate was less than in I and II （P 〈0. 05）. Conclusion： Intraoperative dezocine combined parecoxib in preventing of anesthesia agitation has a good effect, and can reduce the incidence of adverse reactions.