国内轻微肝性脑病研究进展

Domestic Research Progress of Minimal Hepatic Encephalopathy

目的:通过总结分析国内有关轻微肝性脑病(minimal hepatic encephalopathy,MHE)的文献,阐明目前国内MHE的研究现状。方法:选取36篇近10年来国内公开发表的有关MHE发病机理、诊断、防治的文献进行综合阅读及评述。结果:文献报道显示,国内众多学者对MHE的研究取得了一定的进展,但也存在一些问题。结论:MHE的定义尚未完全统一,诊断的金标准尚未完全获得统一认识,无法确定统一的诊断标准;临床研究缺乏大样本的随机对照研究,数据缺乏说服力,可重复性差。这些问题需要我们在今后的研究中加以关注和解决。

Objective：Through analysis of the relevant domestic minimal hepatic encephalopathy（minimal hepatic encephalopathy,MHE） literature,to clarify the current research status of domestic MHE.Method：36 of selection of recent ten years in China the related published MHE pathogenesis,diagnosis,prevention and treatment of comprehensive reading and comment.Results：Reported in the literature shows,domestic scholars research on MHE has made some progress,but there are some problems.Conclusion：MHE definition is not completely uniform,the diagnostic gold standard is not completely unified understanding,cannot determine the uniform diagnostic criteria;lack of clinical research of large sample randomized controlled study,the lack of convincing data stress,poor repeatability.These problems we need in future research to be paid attention to and solved.