慢性阻塞性肺疾病患者血浆脂联素水平及其与白介素17的相关性

Plasma Level of Adiponectin and Its Relationship with Interleukin-17 in Patients with COPD

目的观察COPD急性加重期和稳定期患者血浆脂联素和白介素17(IL-17)水平的变化及其相关性。方法选择正常体重(BM I范围18.5～24.9 kg/m2)的男性COPD患者60例,其中急性加重期30例,稳定期30例。另选同期20例男性非吸烟健康志愿者作为对照组。检测血浆中脂联素和IL-17含量,同时测定肺功能(FEV1%pred和RV%pred)。结果 COPD急性期组血浆脂联素和IL-17水平显著高于稳定期组和健康对照组(P<0.001),COPD稳定期组血浆脂联素和IL-17水平显著高于健康对照组(P<0.01)。COPD急性期组、稳定期组血浆脂联素与IL-17水平呈正相关(r=0.822,P<0.001;r=0.732,P<0.001),与RV%pred呈正相关(rs=0.764,P<0.001;rs=0.967,P<0.001),与FEV1%pred无显著相关性(P>0.05)。结论 COPD患者血浆脂联素水平升高,可能与IL-17以及肺脏过度充气有关。脂联素可能作为一种促炎因子参与了COPD的炎症反应。

Objective To observe the plasma levels of adiponectin and interleukin-17（IL-17） in patients with chronic obstructive pulmonary disease（COPD） at acute exacerbation or stable stage,and analyze their relationship.Methods Sixty male COPD patients with normal weight（with BMI range of 18.5-24.9 kg/m2） were enrolled,including 30 patients with acute exacerbations of COPD（AECOPD） and 30 patients with stable COPD.Twenty healthy nonsmoking male volunteers were included as controls.The plasma levels of adiponectin and IL-17 as well as lung function（FEV1%pred and RV%pred） were measured in all subjects.Results The concentrations of adiponectin and IL-17 were significantly higher in the AECOPD patients than those of the patients with stable COPD and the contro1s（P0.001）.The concentrations of adiponectin and IL-17 were significantly higher in the patients with stable COPD than those of the controls（P0.01）.Adiponectin was positively correlated with IL-17 in the AECOPD patients（r=0.822,P0.001） and in the patients with stable COPD（r=0.732,P0.001）.Adiponectin was positively correlated with RV%pred in the AECOPD patients（rs=0.764,P0.001） and in the patients with stable COPD（rs=0.967,P0.001）.There was no significant relationship between adiponectin and FEV1%pred（P0.05）.Conclusions The plasma level of adiponectin in COPD patients is elevated which is related with excessive inflation of lung.Adiponectin may be involved in the process of inflammation in COPD as a new pro-inflammatory cytokine.