β_2-微球蛋白与冠心病患者冠脉病变程度的相关性分析

Correlation between serum β_2-microglobulin level and severity of coronary artery disease

目的:探讨冠心病患者血清β2-微球蛋白(β2-MG)与冠状动脉粥样硬化病变程度的关系。方法:选择249例行冠状动脉造影检查的患者,将其分为冠心病组和非冠心病组,用ELISA法检测血清β2-MG水平,依据SYNTAX积分进一步分成亚组,比较各组血清β2-MG水平的差异及与冠状动脉病变程度的相关性。结果:冠心病组血清β2-MG水平明显高于健康对照组(P<0.01);随着SYTAX积分的升高,冠状动脉病变愈严重,血清β2-MG水平愈高。血清β2-MG水平与冠状动脉狭窄程度呈正相关,相关系数r=0.51(P<0.01)。结论:冠心病患者血清β2-MG水平与冠状动脉硬化程度呈正相关。

AIM： To investigate the correlation between serum β2-microglobulin（β2-MG） level and coronary stenosis degree in coronary artery disease（CAD）.METHODS： A total of 249 patients undergoing selective coronary angiography were enrolled in this study.The patients were classified into the CAD group and the non-CAD group.The immunity transmission turbidity method was applied to measure serum β2-MG concentration.The possible correlation of serum β2-MG level and SYNTAX score were studied by linear correlation.RESULTS： The levels of serum β2-MG in the CAD group were significantly different from those in the control group（P0.01）.Serum β2-MG level increased along with the extents of coronary stenosis and had a positive association with SYNTAX score（r=0.51,P0.01）.CONCLUSION： A positive correlation exists between serum β2-MG level and severity of coronary stenosis.