摘要
目的探讨P16、Ki-67和端粒酶在浸润性宫颈癌及宫颈上皮内瘤变(CIN)组织中的表达及意义。方法应用免疫组化S-P法检测不同宫颈病变(慢性宫颈炎20例、CINⅠ26例、CINⅡ25例、CINⅢ29例、浸润性宫颈癌30例)组织中P16、Ki-67和端粒酶的表达。结果 P16、Ki-67及端粒酶在慢性宫颈炎组织、不同级别CIN组织及浸润性宫颈癌组织中的表达总体比较差异均有统计学意义(P<0.05)。结论 P16、Ki-67及端粒酶的表达与宫颈癌的发生、发展有关。
Objective To investigate the expressions and significance of P16, Ki-67 and telomerase in invasive cervical carcinoma and cervi- cal intraepithelial neoplasia (CIN). Methods Immunohistochemical S-P method was used to detect the expressions of P16, Ki-67 and telomerase in cervical tissues (20 cases of chronic cervicitis, 26 cases of CIN Ⅰ , 25 cases of CIN Ⅱ , 29 cases CIN Ⅲ, 30 cases of invasive cervical carcinoma). Results There were the statistical differences in the expressions of P16, Ki-67 and telomerase among chrorfic cervicitis, CIN , CIN Ⅱ , CINⅢ , and invasive cervical carcinoma (P 〈 0.05). Conclusion The expressions of PI6, Ki-67 and telomerase are related to the generation and development of cervical carcinoma.
出处
《肿瘤基础与临床》
2011年第6期482-484,共3页
journal of basic and clinical oncology