丙戊酸钠与双丙戊酸钠的毒性比较

Comparing the Toxicity of Valproate Sodium with Divalproex Sodium

目的比较丙戊酸钠与双丙戊酸钠2种供试品毒性的大小。方法采用大鼠和小鼠2种动物,分别灌胃给予不同剂量的丙戊酸钠和双丙戊酸钠,观察大鼠和小鼠的毒性反应症状、死亡情况、病理变化,并计算出供试品对2种动物的LD50值。结果 2种供试品对大鼠和小鼠的毒性反应症状及病理变化基本一致,但是在剂量相当的情况下丙戊酸钠的毒性反应症状比双丙戊酸钠的严重,死亡的动物数更多,LD50值更小。结论丙戊酸钠的毒性比双丙戊酸钠的毒性大。

Objective To compare the toxicity of Valproate sodium with Divalproex sodium. Methods Respectively administered different dose of Valproate sodium and Divalproex sodium to rats and mice, observed the toxicity symptoms, death and pathological change, and calculated the LD50 of the two kinds of animals. Results The toxicity symptoms and pathological change are similar, but the toxicity symptoms of Valproate sodium is more serious and there are more animal death comparing with Divalproex sodium under the proximate dosage. Conclusion The toxicity of Valproate sodium is bigger than Divalproex sodium.