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辛苍滴鼻凝胶剂对哮喘大鼠血、肺泡灌洗液中IL-4、IFN-γ及嗜酸性粒细胞计数的影响 被引量:6

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摘要 目的:观察辛苍滴鼻凝胶剂对哮喘大鼠血清及肺泡灌洗液(BALF)中干扰素γ(IFN-γ)、白介素4(IL-4)、嗜酸性粒细胞(EOS)含量的影响。方法:以卵蛋白致敏并吸入激发法制备大鼠哮喘模型,造模成功后随机分为模型组、辛苍滴鼻凝胶组、辛苍汤组和地塞米松组,另取健康雄性Wistar大鼠7只设为正常组。实验第22天开始给药干预,治疗3周后处死大鼠,观察各组大鼠血清及BALF中IFN-γ、IL-4含量和EOS计数。结果:与模型组比较,各治疗组大鼠外周血嗜酸性粒细胞计数水平明显降低,血清及BALF中IL-4水平显著降低,IFN-γ水平明显升高。与辛苍汤组比较,辛苍滴鼻凝胶组外周血嗜酸性粒细胞计数水平,血清及BALF中IL-4、IFN-γ水平差异均无统计学意义。结论:辛苍滴鼻凝胶剂通过调节Th1/Th2细胞因子之间的平衡,抑制EOS的趋化,达到防治哮喘的目的。
作者 黄勋 陈伟斌
出处 《江苏中医药》 CAS 2012年第1期72-74,共3页 Jiangsu Journal of Traditional Chinese Medicine
基金 上海市卫生局中医药科研基金(2010L031B)
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