高分辨力MRI测量中国汉族正常成人豆状核

Measuring the volume of the lentiform nucleus in healthy Chinese adults based on high-resolution MRI

目的测量中国汉族正常成人豆状核体积,为建立中国成人数字标准脑提供基础数据。方法采用多中心临床研究形式,选取18~80岁健康志愿者1000名,按照年龄18~30、31~40、41~50、51~60、61~80岁进行分组,每组男、女各100名。采用三维磁化强度预备梯度回波T1 W序列扫描获取图像,应用三维体积分析软件手工勾绘ROI,测量豆状核的体积,探讨豆状核体积与年龄的相关关系。结果 1000名正常成人左、右侧壳核体积分别为（4811.59±588.99）mm3和（4763.11±587.59）mm3,左侧壳核体积大于右侧（t=10.134,P〈0.0001）;左、右侧苍白球体积分别为（1591.31±226.81）mm3、（1627.28±235.06）mm3,左侧苍白球体积小于右侧（t=-9.877,P〈0.0001）。男性左、右侧壳核体积和苍白球体积分别为（4962.72±598.49）mm3、（4909.83±600.54）mm3、（1623.24±234.16）mm3和（1663.18±243.56）mm3;女性左、右侧壳核及苍白球体积分别为（4663.65±540.49）mm3、（4619.28±537.59）mm3、（1560.00±215.04）mm3、（1592.09±221.06）mm3,男性体积均大于女性（P均〈0.0001）。左、右侧壳核及左、右侧苍白球体积均随年龄增长而减低。结论正常成人豆状核中,壳核体积左侧大于右侧,苍白球体积右侧大于左侧;男性豆状核体积大于女性。豆状核体积均随年龄增大而减小。

Objective To measure the volume of the lentiform nucleus in Chinese adults of Han nationality,in order to provide database for researching on a variety of diseases associated with lentiform nucleus.Methods Totally 1000 volunteers（aged from 18 to 70） were recruited in this multi-center study and divided into 5 groups according to the age（18—30,31—40,41—50,51—60,61—80）.Each group included 100 men and 100 women.All the volunteers underwent MR examination using T1 weighted three-dimensional magnetization prepared rapid acquisition gradient echo sequence.The volume of lentiform nucleus was measured manually using 3D volume analysis software.The relationship between the volume of lentiform nucleus and age,as well as sex was analyzed.Results The mean volume of left and right putamen in 1000 volunteers were（4811.59±588.99）mm3 and（4763.11±587.59）mm3,and the volume of left putamen was larger than that of right putamen（t=10.134,P0.0001）.The mean volume of left and right globus pallidus were（1591.31±226.81）mm3 and（1627.28±235.06）mm3,and the volume of right globus pallidus was larger（t=-9.877,P0.0001）.The mean volume of left and right putamen and globus pallidus were（4962.72±598.49）mm3,（4909.83±600.54）mm3,（1623.24±234.16）mm3 and（1663.18±243.56）mm3,respectively for men,while for women were（4663.65±540.49）mm3,（4619.28±537.59）mm3,（1560.00±215.04）mm3 and（1592.09±221.06）mm3,respectively.Men had larger putamen and globus pallidus than women（all P0.0001）.The volume of the left and right putamen,as well as the left and right globus pallidus were all negatively correlated with age.Conclusion The volume of the left putamen is larger than that of the right,and the volume of the right globus pallidus is larger than that of the left.Men have larger lentiform nucleus than the women.The volume of lentiform nucleus loss with aging.