TGF-β_1在牙萌出时的表达及意义

Expression of TGF-β_1 in oral mucosa during tooth eruption and its significance

目的观察萌出前后,转化生长因子-β1(transforming growth factor-β1,TGF-β1)在口腔黏膜中的表达,探讨TGF-β1在牙齿萌出时软组织通道形成中可能发挥的作用。方法免疫组化法检测牙齿萌出过程中,转化生长因子-β1在牙萌出部位口腔黏膜的表达变化。结果牙齿萌出时,TGF-β1在萌出牙齿冠方黏膜的角化层及基底层呈阳性表达,在上皮团呈强阳性表达。而牙齿萌出后,TGF-β1在口腔黏膜的固有层少量表达。结论转化生长因子-β1可能促进萌出牙齿冠方实性上皮团的形成及细胞凋亡,从而参与软组织通道的建立。

Objective To investigate the expression and localization of TGF-β1 in the tissues of oral mucosa and explore the possible role of TGF-β1 in the formation of soft tissue passage during tooth eruption. Methods Immunohistochemical technique was used to localize the distri- bution of TGF-β1 in oral mucosa located in the corona of the erupting molars. Results In the eruputing tooth, TGF-β1 was located in the stratum corneum and stratum basale of oral epitheli- um, and positively expressed in the epithelial mass. TGF-β1 was negatively expressed in lamina propria at completely erupted tooth oral mucosa. Conclusion TGF-β1 might facilitate the for- mation and apoptosis of the epithelial mass. It may play an important role in the formation of the soft tissue passage during tooth eruption.