病程和体重对2型糖尿病胰岛功能的影响

The effects of disease duration and body weight on insulin secretion ability in type 2 diabetes

目的:分析病程和体重对2型糖尿病患者胰岛素分泌能力的影响。方法:以横断面研究的方法,分析不同病程组3个胰岛素分泌指数(HOMA-β、INSR30、INSR120)与初诊断组的变化,并比较超重和肥胖患者的3个胰岛素分泌指数和相同病程非肥胖患者的差异。结果:胰岛素分泌功能随病程延长而逐步衰退,与初诊断组相比,病程超过2年后统计学差异显著。超重和肥胖患者的胰岛素分泌能力强于同病程的非肥胖患者,但病程达15年以上时这种差异消失。病程2～4年的超重和肥胖患者INSR30、INSR120与初诊断组比较分别升高9.40%、5.39%,与非肥胖患者的胰岛素分泌能力有显著性差异。结论:2型糖尿病患者胰岛素分泌能力随病程延长而逐步衰退,超重和肥胖患者的分泌能力和随病程变化模式与非肥胖患者间存在差异。

Objective：To evaluate the effects of disease duration and body weight on insulin secretion in type 2 diabetes.Methods：Type 2 diabetic patients were divided to groups according to the disease duration,and three insulin secretion indices（HOMA-β,INSR30,INSR120） of all groups were compared with the newly diagnosed group and the parameters in overweight / obese patients were compared with non-obese patients with same disease duration.Results：The insulin secretion ability decreased gradually as the disease duration extended.The statistical differences appeared when the disease duration exceeded 2 years.Insulin secretion was significantly higher in overweight / obese patients than that of non-obese one with the same disease duration.INSR30 and INSR120 increased 9.40% and 5.39% in overweight / obese patients with 2 to 4 years diabetes,respectively,when compared with newly onset group.Conclusion：Insulin secretion ability decreases with type 2 diabetes duration.There are differences of both insulin secretion ability and mode of change between overweigh / obese patients and non-obese one.