南宁地区HIV/AIDS患者药物不良反应报告分析

Analysis on adverse drug reaction of HIV/AIDS patient in Nanning city

目的了解该南宁区人类免疫缺陷病毒(HIV)/获得性免疫缺陷综合征(AIDS)患者药物不良反应(ADR)的发生情况及特点。方法对该院2009年5月-2010年10月收到的192例HIV/AIDS住院患者的ADR报告进行统计、分析。结果在192例ADR中,男性(60.4%)高于女性(39.6%);23～40岁发生率最高(52.6%);静脉给药方式是导致ADR的主要途径(63.5%);引起不良反应最常见药物是抗感染药,其中抗生素占40.7%、抗HIV药占26.2%、抗结核药占17.9%。最多见受损器官是皮肤及附属器官(40.1%),其次是消化系统(占20.3%)和血液系统(12.0%)。结论 HIV/AIDS患者ADR以抗感染药为主,应加强对抗机会性感染药物和抗HIV药物的监测。

Objective To investigate the incidence and characteristic of adverse drug reaction（ADR） in patient with human immunodeficiency virus（HIV）/acquired immune deficiency syndrome（AIDS）.Methods Analyzed ADR report of 192 cases HIV/AIDS inpatient in hospital of nanning.Results In 192 cases of ADR,males（60.4%） was higher than females（39.6%）,the incidence of 23~40 years was highest（52.6%）,intravenous infusion was the main way leading to ADR（63.5%）.The most common adverse reaction caused by anti-infective drugs,including antibiotics accounted for 40.7%,anti-HIV drugs for 26.2%,anti-TB drugs accounted for 17.9%.The most common damage to organs and subsidiary organs of the skin（40.1%）,followed by the digestive system（20.3%） and blood（12.0%）.Conclusion HIV/AIDS patients ADR is dominated by anti-infectives,should strengthen fight against drugs for opportunistic infections and anti-HIV drug monitoring.