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二氧化碳激发试验评估脑血管储备功能的临床研究 被引量:1

Clinical study on carbon dioxide challenge for evaluation of cerebrovascular reserve
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摘要 目的:应用5%CO2作为血管扩张介质,通过CT灌注成像(CTPI)及CT血管成像(CTA)分析基础状态和激发状态下正常受试者脑血流动力学及脑血管储备功能变化特点和临床意义。方法:对30名排除肺部和心脏疾病的正常受试者行基础态CTPI和CTA检查,吸入5%CO2和95%O2混合气体2min后行CTPI检查。结果:CO2激发试验后呼气末CO2分压、平均动脉压和脉搏的平均值分别为(42.33±5.06)mmHg、(100.96±18.27)mmHg和(78.37±14.68)次/分。脑皮层兴趣区激发前后脑血流量(CBF)和脑血容量(CBV)差异有统计学意义(P<0.05);激发前后达峰时间(TTP)无显著性差异。结论:5%CO2可作为良好的血管扩张介质用于临床脑血管疾病患者的脑血流动力学及脑血管储备功能的研究。 Objective:To investigate the clinical significance of differences between rest and challenge state of cerebrovascular hemodynamics and cerebrovascular reserves features of normal subjects by using CT perfusion Imaging(CTPI) and CT angiography(CTA).Methods:30 normal subjects excluded heart and lung diseases underwent CTPI and CTA in rest state,and then performed CTPI after inhaling 5% CO2 containing 95% O2 for two minutes consecutively.Results:End expiration pressure of CO2,mean arterial pressure and mean pulse were(42.33±5.06)mmHg、(100.96±18.27)mmHg and(78.37±14.68)bpm.Between rest and challenge state,cerebral blood flow and cerebral blood volume showed obviously statistical differences(P0.05),but time to peak showed no statistical differences.Conclusion:5% CO2 is good vasodilator in studying cerebral hemodynamics and cerebrovascular reserves of patients with cerebrovascular disease.
出处 《放射学实践》 北大核心 2011年第12期1249-1252,共4页 Radiologic Practice
关键词 二氧化碳 灌注 体层摄影术 X线计算机 脑血流动力学 Carbon dioxide Perfusion Tomography X-ray computed Cerebral hemodynamics
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