期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

钙结合蛋白S100A12在动脉粥样硬化中的作用 被引量：5

下载PDF
导出
摘要 钙结合蛋白S100A12作为具有EF手型结构的S100蛋白家族中的较新一员,有着其独特的结构与功能。人S100A12主要由中性粒细胞表达和分泌,也可被单核细胞及巨噬细胞诱导表达,其通过Ca2+、Zn2+等调节构象变化,结合特异性配体在体内参与多种生理及病理过程。S100A12作为单核细胞趋化剂,活化肥大细胞,在体内形成嗜中性粒细胞和巨噬细胞聚集。因此,S100A12可能对动脉粥样硬化的形成、进展及预后起着非常重要的作用。
作者 贺骞 孙建辉
机构地区 苏州大学附属第三医院(常州市第一人民医院)心内科
出处 《国际心血管病杂志》 2012年第1期1-3,21,共4页 International Journal of Cardiovascular Disease
关键词 钙结合蛋白 S100A12 促炎症因子 动脉粥样硬化
分类号 R543.5 [医药卫生—心血管疾病]
  • 相关文献

参考文献21

  • 1Marenholz I, Heizmann C W, Fritz G. S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature) [J]. Biochem Biophys Res Commun, 2004, 322(4):1111-1122.
  • 2Cole A M, Kim Y H, Tahk S, et al. Caleitermin, a novel antimicrobial peptide isolated from human airway secretions [J]. FEBS Lett, 2001, 504(1-2):5-10.
  • 3Moroz O V,Burkitt W, Wittkowski H, et al. , Both Ca2 + and Zn2 + are essential for S100A12 protein oligomerization and function[J]. BMC Biochem,2009, 10:11.
  • 4Yang Z, Tao T, Raftery M J, et al. Proinflamrnatory properties ofthe human S100 protein S100A12[J]. J Leukoe Biol, 2001, 69 (6): 986-994.
  • 5Hasegawa T, Kosaki A, Kimura T, et al. The regulation of EN-RAGE (S100A12) gene expression in human THP-1 macrophages[J]. Atheroselerosis, 2003, 171(2) : 211-218.
  • 6Rouleau P, Vandal K, Ryckman C, et al. The calciumbinding protein S100A12 induces neutrophil adhesion, migration, and reiease from hone marrow in mouse at concentrations similar to those found in human inflammatory arthritis[J]. Clin Immunol, 2003, 107(1): 46-54.
  • 7Yang Z, Yan W X, Cai H, et al. S100A12 provokes mast cell activation: a potential amplification pathway in asthma and innate immunity[J]. J Allergy Clin Immunol, 2007, 119(1) : 106-114.
  • 8Hoppmann S, Steinbach J, Pietzseh J. Scavenger receptors are associated with cellular interactions of S100A12 in vitro and in vivo [J]. Int J Biochem Cell Biol, 2010, 42 (5): 651-661.
  • 9Shiotsu Y, Mori Y, Nishimura M, et al. Plasma S100A12 level is associated with cardiovascular Disease in hemodialysis patients[J]. Clin J Am Soe Nephrol, 2011, 6(4) :718-723.
  • 10Mahajan N, Malik N, Bahl A, et al. , Receptor for advanced glycation end products (RAGE) and its inflammatory ligand EN-RAGE in non-diabetic subjects with pre-mature coronary artery disease[J]. Atherosclerosis, 2009, 207(2):597-602.

同被引文献47

  • 1Lippi G, Plebani M, Montagnana M, et al. Biochemical and ge- netic markers of erectile dysfunction [ J]. Adv Clin Chem,2012, 57:139 -62.
  • 2Jackson G. Erectile dysfunction and coronary disease: evaluating the link [J]. Maturitas, 2012,72(3) :263 -4.
  • 3Meijer B, Gearry R B, Day A S. The role of S100A12 as a sys- temic marker of inflammation [ J ]. Int J Inflam, 2012,2012: 907078.
  • 4Vince R V, Chrismas B, Midgley A W, et al. Hypoxia mediated release of endothelial microparticles and increased association of S100A12 with circulating neutrophils [ J ]. Oxid Med Cell Longev, 2009,2(1) :2 -6.
  • 5Yao D, Brownlee M. Hyperglycemia-induced reactive oxygen spe- cies increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands [J].Diabetes, 2010,59 ( 1 ) :249.
  • 6Rosen Pt C, Cappelleri J C, Smith M D, et al. Development and evaluation of an abridged, 5-item version of the international index of erectile function ( IIEF-5 ) as a diagnostic tool for erectile dys- function [J]. Int J Impot Res,1999,11 (6) :319 -26.
  • 7Perera C, McNeil H P, Geczy C L, et al. S100 Calgranulins in inflammatory arthritis [J]. Immunol Cell Biol, 2010,88 (1):41 -9.
  • 8余海放,何庆.百草枯中毒与全身炎症反应及NF-κB的关系[J].华西医学,2008,23(1):179-180. 被引量：29
  • 9孙燕玲,吕建国,孟运莲,王秋桂.应激性溃疡对延髓内脏带的影响及雷贝拉唑预处理的作用[J].解剖学杂志,2008,31(6):823-826. 被引量：3
  • 10张炜,孙海晨,邵旦兵,唐文杰,刘红梅,李伟,许宝华,聂时南.急性百草枯中毒的临床分型与预后分析[J].中华急诊医学杂志,2010,19(4):357-360. 被引量：35

引证文献5

二级引证文献26

国际心血管病杂志
2012年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部