ICU尿培养阳性标本的致病菌分布及耐药性分析

Distribution and drug resistance of pathogens from urine culture positive specimens in ICU

目的了解ICU患者尿培养阳性标本的致病菌感染分布及耐药状况,为临床合理用药提供依据。方法回顾性分析2009～2011年湖北医药学院附属人民医院ICU患者尿标本中分离的致病菌分布及耐药状况,用Whonet 5.5软件进行分析。结果分离菌株207株,其中,假丝酵母菌99株,革兰阴性杆菌72株,革兰阳性球菌36株,分别占阳性例数的47.83%、34.78%和17.39%;三类致病菌分别对特比萘芬、喹诺酮类及头孢菌素类抗菌药物表现出较高的耐药率。结论 ICU患者尿培养假丝酵母菌感染率高,致病菌耐药现象严重。应加强ICU尿培养的监测,预防假丝酵母菌感染。

Objective To understand the distribution and drug resistance of pathogens from the positive urine culture specimens in ICU patients,and provide the basis for the clinical use of drugs.Methods The distribution and drug resistance of pathogens from the positive urine culture specimens in ICU patients of the Affiliated People＇s Hospital of Hubei University of Medicine were retrospectively analyzed with software Whonet 5.5.Results Among 207 isolated strains pathogens,including 99 Candida,72 Gram-negative bacterias,36 Gram-positive bacterias,the rates were 47.83%,34.78% and 17.39%.Three pathogens had a higher resistance rates,respectively to Terbinafine,Couinaud ketone and Cephalosporin antibacterial drugs.Conclusion The rate of Candida infections in ICU patients is higher,drug-resistant phenomenon is serious.Urine culture monitoring should be strengthened in order to prevent Candida infections.