纳洛酮对心肺脑复苏作用的评价

Clinical study on the administration of naloxone during closed-chest cardiopulmonary-cerebral resuscitation.

目的 :①观察研究纳洛酮在心肺脑复苏中的作用机理及实际疗效 ;②研究心搏骤停患者血中 β -内啡肽 (以下简称 β -EP)与正常人的差异。 方法 :①随机划分急诊和住院抢救的心搏骤停患者为纳洛酮复苏组与常规复苏组两组。前者以常规复苏为基础 ,再给予纳洛酮2 0mg加生理盐水 2 0ml静注 ,并可间隔 30min多次重复使用。②对常规复苏组和对照组 2 0例健康体检者均抽静脉血 5ml入专用抗凝管离心取血清存放于冰箱、集中一次测定 β -EP。 结果 :纳洛酮组复苏成功率 42 9% ,常规组复苏成功率 14 3% ,纳洛酮组复苏成功率显著高于常规组(P <0 0 5 )。心搏骤停患者血中 β -EP含量较正常人明显增高。 结论 :纳洛酮作为阿片受体纯拮抗剂 ,从多个环节中促进了心肺脑诸器官复苏 。

Objective:(1)To study the effect and mechanism of administrating naloxone(NLX) on cardio-pulmonary-cerebral resuscitation(CPCR).(2)To study the difference of β-EP in blood between patients with cardial arrest(CA) and healthy people.Methods:In patients and emergency room patients receiving CPCR lecause of CA were randomly divided into two groups.Group I was rescured according to routine CPCR method.Group Ⅱ or NLX group was given 2 0 mg NLX in 20ml Normal Saline intravenously which may be repeated many times if necessary after an interval of 30min.Five ml of intravenous blood were drawn from patients with CA to be rescuscired as well as from normal controls into an anticoagulation tube centrifugrd and the serum kept in a refrigegater.All specimem were examined at one seeting.Results:(1)The resuscitation rate 42 9% of group Ⅱ or NLX group was significantly higher than that 14 3% of group Ⅰ or the routine CPCR group(P<0 05).(2)Blood β EP content in patients with CA is significantly than that of normal control.Conclusion:Naloxon,which is an opiate receptor antaginist,definitely participates in cardio pulmonary cerebral resuscitation in several organs by in different ways.