血清CA125水平与先兆流产预后的关系

The relationship between the serum carbohydrate antigen 125 level and the prognosis of the threatened abortion

目的探讨血清CA125水平在预测早期先兆流产妊娠预后的价值。方法对78例早期先兆流产（保胎失败组和保胎成功组）及40例正常早孕妇女治疗前及治疗后1～4周的血清CA125进行测定并比较。结果保胎失败组妇女血清CA125水平为（28．52±19．12）×10^3U／L，显著高于保胎成功组的（28．52±19．12）×10^3U／L、正常孕妇组的（20．45±9．55）×10^3U／L（t=-1．28，-1．24，均P〈0．05），且随着时间的推移而递增，检测敏感性为93．10％，特异性为87．85％。结论血清CA125水平的监测对早孕先兆流产的预后判断具有较高的临床应用价值。

Objective To explore the value of serum CA125 in prediction of the first-trimester threatened abortion. Methods The serum CA125 level of 78 patients with threatened abortionand（ miscarriage success group and failure group） and 40 normal early pregnant women before treatment and after 1 -4 weeks were tested by chemiluminescent immunoassay（CLIA） methods and the results were compared. Results The serum CA125 level of the failure group was significantly higher than that of the miscarriage success group[ （28.52 ± 19.12）×10^3 U/L] and normal early pregnant women group [ （ 20.45±9.55 ）×10^3U/L ] （ t = - 1.28, - 1.24, all P 〈 0.05 ）, and it increased by degree and by time,and the sensitivity and specificity of detection was 93.1% and 87.85% respectively. Conclusion Monitoring of semm CA125 had highly clinical value in predicting the prognosis of threatened abortion.