W/O细乳液的制备及淀粉纳米微球的合成

Preparation of W/O miniemulsion and synthesis of starch nanoparticles

以高压均质为乳化方式,采用细乳液交联法合成淀粉纳米微球。对W/O细乳液制备条件的研究结果表明:Span-80与Tween-80质量比为84∶16,淀粉溶液中NaCl与H2O质量比为6∶100时可制得圆整性和分散性较好的粗乳液;复合乳化剂与环己烷的质量体积比为0.04～0.08g/mL时,细乳液粒径和多分散系数(PDI)变化不明显;随着均质压力的提高,细乳液粒径和PDI逐渐减小;随着均质次数的增加,细乳液粒径和PDI先是逐渐减小,均质5次后变化趋于平缓。以环氧氯丙烷为交联剂,成功制得了粒径约50～100nm淀粉纳米微球。

Starch nanoparticles were prepared by water-in-oil （W/O） miniemulsion-crosslinking method assisted by high-pressure homogenization. The preparation of W/O miniemulsion was study and the results indicated that coarse emulsion of spherical shape with good dispersibility could be prepared at 84 ： 16 mass ratio of Span-80 to Tween-80and 6 ： 100 mass ratio of NaCI to H2O. The Z-average diameter and polydispersity index （PDI） of W/O miniemulsJon changed slightly when the mass-to-volume ratio of compound emulsifier to cyclohexane ranged from 0.04 to 0.08 g/mL, but declined gradually along with the increase in the homogenization pressure. With the increase in homogenization cycle, the Z-average diameter and PDI decreased gradually in the beginning and tended to be stable after 5 cycles, It is demonstrated that starch nanoparticles of 50 - 100 nm can be successfully synthesized in W/O miniemulsion using epichlorohydrin as crosslinking agents,